Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes
Traumatic muscle injuries (TMIs) and muscle pain (MP) negatively impact athletes’ performance and quality of life. Both conditions have a complex pathophysiology involving the interplay between genetic and environmental factors. Yet, the existing data are scarce and controversial. To provide more in...
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| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/6/3300 |
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| author | Inês Soares Marques Valéria Tavares Beatriz Vieira Neto Lucas Rafael Lopes Rodrigo Araújo Goes João António Matheus Guimarães Jamila Alessandra Perini Rui Medeiros |
| author_facet | Inês Soares Marques Valéria Tavares Beatriz Vieira Neto Lucas Rafael Lopes Rodrigo Araújo Goes João António Matheus Guimarães Jamila Alessandra Perini Rui Medeiros |
| author_sort | Inês Soares Marques |
| collection | DOAJ |
| description | Traumatic muscle injuries (TMIs) and muscle pain (MP) negatively impact athletes’ performance and quality of life. Both conditions have a complex pathophysiology involving the interplay between genetic and environmental factors. Yet, the existing data are scarce and controversial. To provide more insights, this study aimed to investigate the association of single-nucleotide polymorphisms (SNPs) previously linked to athletic status with TMI and MP after exercise among Brazilian high-performance athletes from different sports modalities (N = 345). The impact of important environmental determinants was also assessed. From the six evaluated SNPs (<i>ACTN3</i> rs1815739, <i>FAAH</i> rs324420, <i>PPARGC1A</i> rs8192678, <i>ADRB2</i> rs1042713, <i>NOS3</i> rs1799983, and <i>VDR</i> rs731236), none was significantly associated with TMI. Regarding MP after exercise, <i>ACTN3</i> rs1815739 (CC/CT vs. TT; adjusted odds ratio (aOR) = 1.90; 95% confidence interval (95%Cl), 1.01–3.57) and <i>FAAH</i> rs324420 (AA vs. AC/CC; aOR = 2.30; 95%Cl, 1.08–4.91) were independent predictors according to multivariate binomial analyses adjusted for age (≥23 vs. <23 years), sex (male vs. female), and tobacco consumption (yes vs. no). External validation is warranted to assess the predictive value of <i>ACTN3</i> rs1815739 and <i>FAAH</i> rs324420. This could have implications for prophylactic interventions to improve athletes’ quality of life. |
| first_indexed | 2024-04-24T18:11:46Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:11:46Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c495a20afa9142c5b8e004f343db06462024-03-27T13:45:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256330010.3390/ijms25063300Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance AthletesInês Soares Marques0Valéria Tavares1Beatriz Vieira Neto2Lucas Rafael Lopes3Rodrigo Araújo Goes4João António Matheus Guimarães5Jamila Alessandra Perini6Rui Medeiros7Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/Pathology and Laboratory Medicine Dep. Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), 4200-072 Porto, PortugalMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/Pathology and Laboratory Medicine Dep. Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), 4200-072 Porto, PortugalMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/Pathology and Laboratory Medicine Dep. Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), 4200-072 Porto, PortugalPharmaceutical Sciences Research Laboratory (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, BrazilResearch Division, Instituto Nacional de Traumatologia e Ortopedia (INTO), Rio de Janeiro 20940-070, BrazilResearch Division, Instituto Nacional de Traumatologia e Ortopedia (INTO), Rio de Janeiro 20940-070, BrazilPharmaceutical Sciences Research Laboratory (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, BrazilMolecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/Pathology and Laboratory Medicine Dep. Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), 4200-072 Porto, PortugalTraumatic muscle injuries (TMIs) and muscle pain (MP) negatively impact athletes’ performance and quality of life. Both conditions have a complex pathophysiology involving the interplay between genetic and environmental factors. Yet, the existing data are scarce and controversial. To provide more insights, this study aimed to investigate the association of single-nucleotide polymorphisms (SNPs) previously linked to athletic status with TMI and MP after exercise among Brazilian high-performance athletes from different sports modalities (N = 345). The impact of important environmental determinants was also assessed. From the six evaluated SNPs (<i>ACTN3</i> rs1815739, <i>FAAH</i> rs324420, <i>PPARGC1A</i> rs8192678, <i>ADRB2</i> rs1042713, <i>NOS3</i> rs1799983, and <i>VDR</i> rs731236), none was significantly associated with TMI. Regarding MP after exercise, <i>ACTN3</i> rs1815739 (CC/CT vs. TT; adjusted odds ratio (aOR) = 1.90; 95% confidence interval (95%Cl), 1.01–3.57) and <i>FAAH</i> rs324420 (AA vs. AC/CC; aOR = 2.30; 95%Cl, 1.08–4.91) were independent predictors according to multivariate binomial analyses adjusted for age (≥23 vs. <23 years), sex (male vs. female), and tobacco consumption (yes vs. no). External validation is warranted to assess the predictive value of <i>ACTN3</i> rs1815739 and <i>FAAH</i> rs324420. This could have implications for prophylactic interventions to improve athletes’ quality of life.https://www.mdpi.com/1422-0067/25/6/3300sportswounds and injuriespainsports medicinepreventive medicinepolymorphism |
| spellingShingle | Inês Soares Marques Valéria Tavares Beatriz Vieira Neto Lucas Rafael Lopes Rodrigo Araújo Goes João António Matheus Guimarães Jamila Alessandra Perini Rui Medeiros Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes International Journal of Molecular Sciences sports wounds and injuries pain sports medicine preventive medicine polymorphism |
| title | Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes |
| title_full | Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes |
| title_fullStr | Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes |
| title_full_unstemmed | Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes |
| title_short | Genetic Variations in Susceptibility to Traumatic Muscle Injuries and Muscle Pain among Brazilian High-Performance Athletes |
| title_sort | genetic variations in susceptibility to traumatic muscle injuries and muscle pain among brazilian high performance athletes |
| topic | sports wounds and injuries pain sports medicine preventive medicine polymorphism |
| url | https://www.mdpi.com/1422-0067/25/6/3300 |
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