Improving the production of the micafungin precursor FR901379 in an industrial production strain

Improving the production of the micafungin precursor FR901379 in an industrial production strain

Abstract Background Micafungin is an echinocandin-type antifungal agent used for the clinical treatment of invasive fungal infections. It is semisynthesized from the sulfonated lipohexapeptide FR901379, a nonribosomal peptide produced by the filamentous fungus Coleophoma empetri. However, the low fe...

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Bibliographic Details
Main Authors: Ping Men, Yu Zhou, Li Xie, Xuan Zhang, Wei Zhang, Xuenian Huang, Xuefeng Lu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Microbial Cell Factories
Subjects:
Filamentous fungi
Antifungal agent
Micafungin
Metabolic engineering
Coleophoma empetri
Transcriptional activator
Online Access:https://doi.org/10.1186/s12934-023-02050-0

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