Structural Studies of Henipavirus Glycoproteins
Henipaviruses are a genus of emerging pathogens that includes the highly virulent Nipah and Hendra viruses that cause reoccurring outbreaks of disease. Henipaviruses rely on two surface glycoproteins, known as the attachment and fusion proteins, to facilitate entry into host cells. As new and diverg...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/16/2/195 |
| _version_ | 1797296829417652224 |
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| author | Aaron J. May Priyamvada Acharya |
| author_facet | Aaron J. May Priyamvada Acharya |
| author_sort | Aaron J. May |
| collection | DOAJ |
| description | Henipaviruses are a genus of emerging pathogens that includes the highly virulent Nipah and Hendra viruses that cause reoccurring outbreaks of disease. Henipaviruses rely on two surface glycoproteins, known as the attachment and fusion proteins, to facilitate entry into host cells. As new and divergent members of the genus have been discovered and structurally characterized, key differences and similarities have been noted. This review surveys the available structural information on <i>Henipavirus</i> glycoproteins, complementing this with information from related biophysical and structural studies of the broader <i>Paramyxoviridae</i> family of which Henipaviruses are members. The process of viral entry is a primary focus for vaccine and drug development, and this review aims to identify critical knowledge gaps in our understanding of the mechanisms that drive <i>Henipavirus</i> fusion. |
| first_indexed | 2024-03-07T22:11:24Z |
| format | Article |
| id | doaj.art-c4969827266e4789970551b8f44776d3 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-07T22:11:24Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-c4969827266e4789970551b8f44776d32024-02-23T15:37:27ZengMDPI AGViruses1999-49152024-01-0116219510.3390/v16020195Structural Studies of Henipavirus GlycoproteinsAaron J. May0Priyamvada Acharya1Duke Human Vaccine Institute, Duke University, Durham, NC 27710, USADuke Human Vaccine Institute, Duke University, Durham, NC 27710, USAHenipaviruses are a genus of emerging pathogens that includes the highly virulent Nipah and Hendra viruses that cause reoccurring outbreaks of disease. Henipaviruses rely on two surface glycoproteins, known as the attachment and fusion proteins, to facilitate entry into host cells. As new and divergent members of the genus have been discovered and structurally characterized, key differences and similarities have been noted. This review surveys the available structural information on <i>Henipavirus</i> glycoproteins, complementing this with information from related biophysical and structural studies of the broader <i>Paramyxoviridae</i> family of which Henipaviruses are members. The process of viral entry is a primary focus for vaccine and drug development, and this review aims to identify critical knowledge gaps in our understanding of the mechanisms that drive <i>Henipavirus</i> fusion.https://www.mdpi.com/1999-4915/16/2/195HenipavirusRNA virusglycoproteinviral entry |
| spellingShingle | Aaron J. May Priyamvada Acharya Structural Studies of Henipavirus Glycoproteins Viruses Henipavirus RNA virus glycoprotein viral entry |
| title | Structural Studies of Henipavirus Glycoproteins |
| title_full | Structural Studies of Henipavirus Glycoproteins |
| title_fullStr | Structural Studies of Henipavirus Glycoproteins |
| title_full_unstemmed | Structural Studies of Henipavirus Glycoproteins |
| title_short | Structural Studies of Henipavirus Glycoproteins |
| title_sort | structural studies of henipavirus glycoproteins |
| topic | Henipavirus RNA virus glycoprotein viral entry |
| url | https://www.mdpi.com/1999-4915/16/2/195 |
| work_keys_str_mv | AT aaronjmay structuralstudiesofhenipavirusglycoproteins AT priyamvadaacharya structuralstudiesofhenipavirusglycoproteins |