Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome
In the present study, we retrospectively analysed the results of HSCT in 47 consecutive patients with MDS diagnosed at our department between 2002 and 2019, with a focus on possible predictive factors influencing overall survival (OS), the development of relapse, infections, and the occurrence of gr...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
|
| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048921000418 |
| _version_ | 1819000019037978624 |
|---|---|
| author | P Belohlavkova F Vrbacky L Smolej J Radocha M Lanska B Visek T Kupsa A Zavrelova P Zak |
| author_facet | P Belohlavkova F Vrbacky L Smolej J Radocha M Lanska B Visek T Kupsa A Zavrelova P Zak |
| author_sort | P Belohlavkova |
| collection | DOAJ |
| description | In the present study, we retrospectively analysed the results of HSCT in 47 consecutive patients with MDS diagnosed at our department between 2002 and 2019, with a focus on possible predictive factors influencing overall survival (OS), the development of relapse, infections, and the occurrence of graft versus host disease (GvHD). In a univariate analysis, the pre-transplantation value of blasts in the marrow < 5% (p = 0.006), the revised International Prognostic Scoring System (IPSS-R) (p = 0.041), and karyotype (p = 0.009) were predictive of OS. Neither the elevation of serum ferritin (> 1000 ug/ml) nor increased C-reactive protein (CRP) (> 5 mg/l) was associated with shorter OS. In contrast, elevated serum lactate dehydrogenase (LDH) (> 213 U/l) was associated with shorter OS (p = 0.04). |
| first_indexed | 2024-12-20T22:26:39Z |
| format | Article |
| id | doaj.art-c498906680214ac7a5bce79b57f07dda |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-12-20T22:26:39Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-c498906680214ac7a5bce79b57f07dda2022-12-21T19:24:49ZengElsevierLeukemia Research Reports2213-04892021-01-0116100274Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndromeP Belohlavkova0F Vrbacky1L Smolej2J Radocha3M Lanska4B Visek5T Kupsa6A Zavrelova7P Zak8Corresponding author.; 4th Department of Internal Medicine – Haematology, University Hospital and Charles University, Hradec Kralove, Czech Republic4th Department of Internal Medicine – Haematology, University Hospital and Charles University, Hradec Kralove, Czech Republic4th Department of Internal Medicine – Haematology, University Hospital and Charles University, Hradec Kralove, Czech Republic4th Department of Internal Medicine – Haematology, University Hospital and Charles University, Hradec Kralove, Czech Republic4th Department of Internal Medicine – Haematology, University Hospital and Charles University, Hradec Kralove, Czech Republic4th Department of Internal Medicine – Haematology, University Hospital and Charles University, Hradec Kralove, Czech Republic4th Department of Internal Medicine – Haematology, University Hospital and Charles University, Hradec Kralove, Czech Republic4th Department of Internal Medicine – Haematology, University Hospital and Charles University, Hradec Kralove, Czech Republic4th Department of Internal Medicine – Haematology, University Hospital and Charles University, Hradec Kralove, Czech RepublicIn the present study, we retrospectively analysed the results of HSCT in 47 consecutive patients with MDS diagnosed at our department between 2002 and 2019, with a focus on possible predictive factors influencing overall survival (OS), the development of relapse, infections, and the occurrence of graft versus host disease (GvHD). In a univariate analysis, the pre-transplantation value of blasts in the marrow < 5% (p = 0.006), the revised International Prognostic Scoring System (IPSS-R) (p = 0.041), and karyotype (p = 0.009) were predictive of OS. Neither the elevation of serum ferritin (> 1000 ug/ml) nor increased C-reactive protein (CRP) (> 5 mg/l) was associated with shorter OS. In contrast, elevated serum lactate dehydrogenase (LDH) (> 213 U/l) was associated with shorter OS (p = 0.04).http://www.sciencedirect.com/science/article/pii/S2213048921000418Allogeneic haematopoietic stem-cell transplantationMyelodysplastic syndromePrognostic factors |
| spellingShingle | P Belohlavkova F Vrbacky L Smolej J Radocha M Lanska B Visek T Kupsa A Zavrelova P Zak Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome Leukemia Research Reports Allogeneic haematopoietic stem-cell transplantation Myelodysplastic syndrome Prognostic factors |
| title | Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome |
| title_full | Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome |
| title_fullStr | Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome |
| title_full_unstemmed | Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome |
| title_short | Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome |
| title_sort | prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome |
| topic | Allogeneic haematopoietic stem-cell transplantation Myelodysplastic syndrome Prognostic factors |
| url | http://www.sciencedirect.com/science/article/pii/S2213048921000418 |
| work_keys_str_mv | AT pbelohlavkova prognosticfactorsaffectingtheoutcomeafterallogeneichaematopoieticstemcelltransplantationformyelodysplasticsyndrome AT fvrbacky prognosticfactorsaffectingtheoutcomeafterallogeneichaematopoieticstemcelltransplantationformyelodysplasticsyndrome AT lsmolej prognosticfactorsaffectingtheoutcomeafterallogeneichaematopoieticstemcelltransplantationformyelodysplasticsyndrome AT jradocha prognosticfactorsaffectingtheoutcomeafterallogeneichaematopoieticstemcelltransplantationformyelodysplasticsyndrome AT mlanska prognosticfactorsaffectingtheoutcomeafterallogeneichaematopoieticstemcelltransplantationformyelodysplasticsyndrome AT bvisek prognosticfactorsaffectingtheoutcomeafterallogeneichaematopoieticstemcelltransplantationformyelodysplasticsyndrome AT tkupsa prognosticfactorsaffectingtheoutcomeafterallogeneichaematopoieticstemcelltransplantationformyelodysplasticsyndrome AT azavrelova prognosticfactorsaffectingtheoutcomeafterallogeneichaematopoieticstemcelltransplantationformyelodysplasticsyndrome AT pzak prognosticfactorsaffectingtheoutcomeafterallogeneichaematopoieticstemcelltransplantationformyelodysplasticsyndrome |