The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review
Abstract Background Humans’ nervous system has a limited ability to repair nerve cells, which poses substantial challenges in treating injuries and diseases. Stem cells are identified by the potential to renew their selves and develop into several cell types, making them ideal candidates for cell re...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01546-0 |
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| author | Ramyar Rahimi Darehbagh Mozaffar Mahmoodi Nader Amini Media Babahajiani Azra Allavaisie Yousef Moradi |
| author_facet | Ramyar Rahimi Darehbagh Mozaffar Mahmoodi Nader Amini Media Babahajiani Azra Allavaisie Yousef Moradi |
| author_sort | Ramyar Rahimi Darehbagh |
| collection | DOAJ |
| description | Abstract Background Humans’ nervous system has a limited ability to repair nerve cells, which poses substantial challenges in treating injuries and diseases. Stem cells are identified by the potential to renew their selves and develop into several cell types, making them ideal candidates for cell replacement in injured neurons. Neuronal differentiation of embryonic stem cells in modern medicine is significant. Nanomaterials have distinct advantages in directing stem cell function and tissue regeneration in this field. We attempted in this systematic review to collect data, analyze them, and report results on the effect of nanomaterials on neuronal differentiation of embryonic stem cells. Methods International databases such as PubMed, Scopus, ISI Web of Science, and EMBASE were searched for available articles on the effect of nanomaterials on neuronal differentiation of embryonic stem cells (up to OCTOBER 2023). After that, screening (by title, abstract, and full text), selection, and data extraction were performed. Also, quality assessment was conducted based on the STROBE checklist. Results In total, 1507 articles were identified and assessed, and then only 29 articles were found eligible to be included. Nine studies used 0D nanomaterials, ten used 1D nanomaterials, two reported 2D nanomaterials, and eight demonstrated the application of 3D nanomaterials. The main biomaterial in studies was polymer-based composites. Three studies reported the negative effect of nanomaterials on neural differentiation. Conclusion Neural differentiation is crucial in neurological regenerative medicine. Nanomaterials with different characteristics, particularly those cellular regulating activities and stem cell fate, have much potential in neural tissue engineering. These findings indicate a new understanding of potential applications of physicochemical cues in nerve tissue engineering. Graphical Abstract |
| first_indexed | 2024-03-09T01:20:50Z |
| format | Article |
| id | doaj.art-c498f7a9fdb44fa9977fc1c9eba49dc9 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-09T01:20:50Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-c498f7a9fdb44fa9977fc1c9eba49dc92023-12-10T12:12:09ZengBMCEuropean Journal of Medical Research2047-783X2023-12-0128111810.1186/s40001-023-01546-0The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic reviewRamyar Rahimi Darehbagh0Mozaffar Mahmoodi1Nader Amini2Media Babahajiani3Azra Allavaisie4Yousef Moradi5Student Research Committee, Kurdistan University of Medical SciencesCellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical SciencesEnvironmental Health Research Center, Research Institute for Health Development, Kurdistan University of Medical SciencesStudent Research Committee, Kurdistan University of Medical SciencesDepartment of Anatomical Sciences, School of MedicineDepartment of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical SciencesAbstract Background Humans’ nervous system has a limited ability to repair nerve cells, which poses substantial challenges in treating injuries and diseases. Stem cells are identified by the potential to renew their selves and develop into several cell types, making them ideal candidates for cell replacement in injured neurons. Neuronal differentiation of embryonic stem cells in modern medicine is significant. Nanomaterials have distinct advantages in directing stem cell function and tissue regeneration in this field. We attempted in this systematic review to collect data, analyze them, and report results on the effect of nanomaterials on neuronal differentiation of embryonic stem cells. Methods International databases such as PubMed, Scopus, ISI Web of Science, and EMBASE were searched for available articles on the effect of nanomaterials on neuronal differentiation of embryonic stem cells (up to OCTOBER 2023). After that, screening (by title, abstract, and full text), selection, and data extraction were performed. Also, quality assessment was conducted based on the STROBE checklist. Results In total, 1507 articles were identified and assessed, and then only 29 articles were found eligible to be included. Nine studies used 0D nanomaterials, ten used 1D nanomaterials, two reported 2D nanomaterials, and eight demonstrated the application of 3D nanomaterials. The main biomaterial in studies was polymer-based composites. Three studies reported the negative effect of nanomaterials on neural differentiation. Conclusion Neural differentiation is crucial in neurological regenerative medicine. Nanomaterials with different characteristics, particularly those cellular regulating activities and stem cell fate, have much potential in neural tissue engineering. These findings indicate a new understanding of potential applications of physicochemical cues in nerve tissue engineering. Graphical Abstracthttps://doi.org/10.1186/s40001-023-01546-0NanomaterialsEmbryonic stem cellNeural differentiation |
| spellingShingle | Ramyar Rahimi Darehbagh Mozaffar Mahmoodi Nader Amini Media Babahajiani Azra Allavaisie Yousef Moradi The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review European Journal of Medical Research Nanomaterials Embryonic stem cell Neural differentiation |
| title | The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review |
| title_full | The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review |
| title_fullStr | The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review |
| title_full_unstemmed | The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review |
| title_short | The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review |
| title_sort | effect of nanomaterials on embryonic stem cell neural differentiation a systematic review |
| topic | Nanomaterials Embryonic stem cell Neural differentiation |
| url | https://doi.org/10.1186/s40001-023-01546-0 |
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