Advanced Glycation End Product (AGE)-AGE Receptor (RAGE) System Upregulated Connexin43 Expression in Rat Cardiomyocytes via PKC and Erk MAPK Pathways

Advanced Glycation End Product (AGE)-AGE Receptor (RAGE) System Upregulated Connexin43 Expression in Rat Cardiomyocytes via PKC and Erk MAPK Pathways

The remodeling of cardiac gap junction contributes to the arrhythmias in a diabetic heart. We previously reported that high glucose reduced Cx43 protein level in neonatal rat cardiomyocytes. But, the effect and mechanisms of advanced glycation end product (AGE) on Cx43 expression still remain unclea...

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Bibliographic Details
Main Authors: Shaoxiang Weng, Guosheng Fu, Chongying Jin, Fang Ding, Shengjie Xu, Yanbo Zhao, Lu Yu
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:International Journal of Molecular Sciences
Subjects:
advanced glycation end product
connexin43
cardiomyocytes
diabetes
Online Access:http://www.mdpi.com/1422-0067/14/2/2242

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