| Summary: | Guiyun Zhang,1 Yufeng Lu,2 Bin Liu,3 Yanmei Wang,4 Wenyi Li,1 Yangchun Xu1 1Department of Dermatology, The Second Hospital of Jilin University, Changchun, 130041, People’s Republic of China; 2Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130000, People’s Republic of China; 3Department of Breast Surgery, The Second Hospital of Jilin University, Changchun, 130041, People’s Republic of China; 4Department of Clinical Nutrition, Jilin Province People’s Hospital, Changchun, 130021, People’s Republic of ChinaCorrespondence: Yangchun Xu, Department of Dermatology, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Nanguan District, Changchun, 130041, People’s Republic of China, Tel +86-431-8113-6244, Email xuyc@jlu.edu.cnIntroduction: Bowen’s disease (BD) commonly occurs in sites of chronic sunlight exposure such as head, neck and extremities. It rarely distributes on the nipple and areola.Case Presentation: A 59-year-old female presented with crusted plaque on the right breast for over 1 month. Physical examination found an asymptomatic plaque (5 cm × 5 cm) with irregular shape on the right breast. Histopathological examination suggested irregularly acanthotic epidermis and atypical epidermal cells. Dermis showed inflammatory cell infiltration. Immunohistochemical staining showed negative staining for cytokeratin 7 and cytokeratin 20, and positive staining for Ki67 (60%). The mass was excised and no recurrence occurred in the follow-up. Additionally, we reviewed the literature about BD of the breast and summarized the clinical manifestations, histological features, and treatment options.Conclusion: We reported a rare BD case involving nipple and areola. Wide local excision and complete nipple excision are effective for patients with BD of the nipple and areola.Keywords: Bowen’s disease, breast, nipple, case report
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