The relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and ART outcomes
Background: Oxidative stress (OS) in the follicular environment may affect on oocyte competence and antioxidant vitamins may modify its effects. Objective: This study was conducted to examine the effect of dietary intake of vitamin A, C and E on OS in follicular environment and assisted reproducti...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Science, Yazd, Iran
2015-09-01
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| Series: | Iranian Journal of Reproductive Medicine |
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| Online Access: | http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1645/890 |
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| author | Ashraf Kazemi Fatemeh Ramezanzadeh Mohammad Hosein Nasr-Esfahani |
| author_facet | Ashraf Kazemi Fatemeh Ramezanzadeh Mohammad Hosein Nasr-Esfahani |
| author_sort | Ashraf Kazemi |
| collection | DOAJ |
| description | Background: Oxidative stress (OS) in the follicular environment may affect on oocyte competence and antioxidant vitamins may modify its effects.
Objective: This study was conducted to examine the effect of dietary intake of vitamin A, C and E on OS in follicular environment and assisted reproduction technology (ART) outcomes.
Materials and Methods: In this obsevationalprospective study, the intake levels of vitamin A, C, and E were matured by validated food frequency questionnaire and Malondialdehyde and the total antioxidant capacity (TAC) levels of follicular fluid (FF) in 219 women undergoing ART were assessed. The number of retrieved oocytes, percentages of metaphase II MII) stage oocytes, fertilization rate, and embryo quality were also determined.
Results: No significant association was found between vitamins intake levels and OS biomarkers, but the mean of TAC level in FF among women who received vitamin C greater than 75 mg/d was higher than women with lower intakes (p<0.05). The ART parameters were not related to the vitamin E intake level, but the normal cleaved embryo rate was positively related to vitamin A (p<0.05) and vitamin C (p=0.02) intake levels. Also, the percentage of MII oocytes (p=0.02) and the fertilization rate (p<0.05) were related to the vitamin C intake level. The relation between the TAC level in FF and ART outcomes were not significant.
Conclusion: Current results indicated that high dietary intake of vitamin C would be followed by increasing the TAC level in FF and improving the oocyte competence, but this effect of vitamin C is not dependent of increasing of antioxidant defense in follicular environment. |
| first_indexed | 2024-12-13T21:46:56Z |
| format | Article |
| id | doaj.art-c49efb1a926c48bd863ebaf9ffd2f6b2 |
| institution | Directory Open Access Journal |
| issn | 1680-6433 2008-2177 |
| language | English |
| last_indexed | 2024-12-13T21:46:56Z |
| publishDate | 2015-09-01 |
| publisher | Shahid Sadoughi University of Medical Science, Yazd, Iran |
| record_format | Article |
| series | Iranian Journal of Reproductive Medicine |
| spelling | doaj.art-c49efb1a926c48bd863ebaf9ffd2f6b22022-12-21T23:30:24ZengShahid Sadoughi University of Medical Science, Yazd, IranIranian Journal of Reproductive Medicine1680-64332008-21772015-09-01139533540The relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and ART outcomesAshraf Kazemi0Fatemeh Ramezanzadeh1Mohammad Hosein Nasr-Esfahani2Reproductive Health Department, Nursing and Midwifery Care Research Centere, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, IranVali-e-Asr Reproductive Health Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranReproductive Biomedicine Center, Royan Institute for Animal Biotechnology, ACECR, Department of Reproduction and Development, Isfahan, IranBackground: Oxidative stress (OS) in the follicular environment may affect on oocyte competence and antioxidant vitamins may modify its effects. Objective: This study was conducted to examine the effect of dietary intake of vitamin A, C and E on OS in follicular environment and assisted reproduction technology (ART) outcomes. Materials and Methods: In this obsevationalprospective study, the intake levels of vitamin A, C, and E were matured by validated food frequency questionnaire and Malondialdehyde and the total antioxidant capacity (TAC) levels of follicular fluid (FF) in 219 women undergoing ART were assessed. The number of retrieved oocytes, percentages of metaphase II MII) stage oocytes, fertilization rate, and embryo quality were also determined. Results: No significant association was found between vitamins intake levels and OS biomarkers, but the mean of TAC level in FF among women who received vitamin C greater than 75 mg/d was higher than women with lower intakes (p<0.05). The ART parameters were not related to the vitamin E intake level, but the normal cleaved embryo rate was positively related to vitamin A (p<0.05) and vitamin C (p=0.02) intake levels. Also, the percentage of MII oocytes (p=0.02) and the fertilization rate (p<0.05) were related to the vitamin C intake level. The relation between the TAC level in FF and ART outcomes were not significant. Conclusion: Current results indicated that high dietary intake of vitamin C would be followed by increasing the TAC level in FF and improving the oocyte competence, but this effect of vitamin C is not dependent of increasing of antioxidant defense in follicular environment.http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1645/890Oxidative stressVitamin AVitamin CVitamin EAssisted reproductionFertilizationEmbryo quality |
| spellingShingle | Ashraf Kazemi Fatemeh Ramezanzadeh Mohammad Hosein Nasr-Esfahani The relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and ART outcomes Iranian Journal of Reproductive Medicine Oxidative stress Vitamin A Vitamin C Vitamin E Assisted reproduction Fertilization Embryo quality |
| title | The relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and ART outcomes |
| title_full | The relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and ART outcomes |
| title_fullStr | The relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and ART outcomes |
| title_full_unstemmed | The relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and ART outcomes |
| title_short | The relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and ART outcomes |
| title_sort | relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and art outcomes |
| topic | Oxidative stress Vitamin A Vitamin C Vitamin E Assisted reproduction Fertilization Embryo quality |
| url | http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1645/890 |
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