Colonic expression of glutathione S-transferase alpha 4 and 4-hydroxynonenal adducts is correlated with the pathology of murine colitis-associated cancer

Colonic expression of glutathione S-transferase alpha 4 and 4-hydroxynonenal adducts is correlated with the pathology of murine colitis-associated cancer

Chronic inflammation-induced oxidative stress is an important driving force for developing colitis-associated cancer (CAC). 4-hydroxynonenal (4-HNE) is a highly reactive aldehyde derived from lipid peroxidation of ω-6 polyunsaturated fatty acids that contributes to colorectal carcinogenesis. Glutath...

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Bibliographic Details
Main Authors: Chunhua Ma, Zhanhu Zhang, Tianqi Li, Yumei Tao, Guoxiang Zhu, Lili Xu, Yuanyuan Ju, Xu Huang, Jinyun Zhai, Xingmin Wang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Heliyon
Subjects:
Colitis-associated cancer
4-Hydroxynonenal
Glutathione S-Transferase alpha 4
AOM/DSS
Inflammatory cytokines
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023070238

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