Prognostic PET [11C]-acetate uptake is associated with hypoxia gene expression in patients with late-stage hepatocellular carcinoma – a bench to bed study

Prognostic PET [11C]-acetate uptake is associated with hypoxia gene expression in patients with late-stage hepatocellular carcinoma – a bench to bed study

Abstract Background Positron Emission Tomography (PET) with combined [18F]-FDG and [11C]-acetate (dual-tracer) is used for the management of hepatocellular carcinoma (HCC) patients, although its prognostic value and underlying molecular mechanism remain poorly understood. We hypothesized that radiot...

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Bibliographic Details
Main Authors: Keith Wan Hang Chiu, Kel Vin Tan, Xinxiang Yang, Xiaoqiang Zhu, Jingjing Shi, Chi-Leung Chiang, Lawrence Chan, Yuan Hui, Pek-Lan Khong, Kwan Man, Jason Wing Hon Wong
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cancer Imaging
Subjects:
Hepatocellular carcinoma
Hypoxia
PET imaging
RNA sequencing
[11C]-acetate
Online Access:https://doi.org/10.1186/s40644-024-00685-9

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