PDK4 Constitutes a Novel Prognostic Biomarker and Therapeutic Target in Gastric Cancer
Gastric cancer (GC) is one of the most prevalent and deadly malignancies worldwide. We aimed to assess the functional role and clinical significance of pyruvate dehydrogenase kinase (PDK) in GC and explored the underlying mechanisms. The bioinformatics method was used to investigate the expression o...
Main Authors: | Zimu Zhang, Shiyuan Han, Siwen Ouyang, Ziyang Zeng, Zhen Liu, Juan Sun, Weiming Kang |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-04-01
|
Series: | Diagnostics |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-4418/12/5/1101 |
Similar Items
-
Deficiency of TOP1MT enhances glycolysis through the stimulation of PDK4 expression in gastric cancer
by: Hongqiang Wang, et al.
Published: (2024-01-01) -
PDK1- and PDK2-mediated metabolic reprogramming contributes to the TGFβ1-promoted stem-like properties in head and neck cancer
by: Wan-Hsuan Sun, et al.
Published: (2022-12-01) -
The Landscape of PDK1 in Breast Cancer
by: Na Wang, et al.
Published: (2022-02-01) -
Pan-cancer analysis reveals PDK family as potential indicators related to prognosis and immune infiltration
by: Shigui Tao, et al.
Published: (2024-03-01) -
Conditional knockout of PDK1 in osteoclasts suppressed osteoclastogenesis and ameliorated prostate cancer-induced osteolysis in murine model
by: Yanan Zhang, et al.
Published: (2023-10-01)