Cytotoxic Activity of Some Azole Derivatives
Azole derivatives are an important class of compounds in medicinal chemistry with a wide variety of biological activities. We previously described synthesis and antimicrobial evaluations of some new Azole derivatives. Most of our compounds showed desirable activity against different species of micro...
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| Format: | Article |
| Language: | English |
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West Asia Organization for Cancer Prevention
2018-11-01
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| Series: | Asian Pacific Journal of Cancer Biology |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcb/article/view/239 |
| _version_ | 1797341171016531968 |
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| author | Zeinab Faghih Zahra Rezaei Akram Jamshidzade Aboozar Keshavarz Soghra Khabnadideh |
| author_facet | Zeinab Faghih Zahra Rezaei Akram Jamshidzade Aboozar Keshavarz Soghra Khabnadideh |
| author_sort | Zeinab Faghih |
| collection | DOAJ |
| description | Azole derivatives are an important class of compounds in medicinal chemistry with a wide variety of biological activities. We previously described synthesis and antimicrobial evaluations of some new Azole derivatives. Most of our compounds showed desirable activity against different species of microorganisms. Here, we chose seventeen of these compounds, in four different groups including imidazole (group a, 1a-6a), 2-methylimidazole (group b, 1b-4b), 2-methyl-4-nitroimidazole (group c, 1c-4c) and benzimidazole (group d, 1d-3d) to further evaluate their cytotoxic activities against a human cancer cell line (HepG2) in comparison to cisplatin using colorimetric MTT cytotoxic assay. We also compared their cytotoxic activities with clotrimazole to find the safer compounds as antimicrobial agents. Our results indicated that Azole compounds including 2b, 4c, 2d and 3d displayed desirable anti-tumor activities against HepG2 (IC50<50μM) and might be considered as potential anticancer agents for further studies. The o her compounds with less cytotoxicity compared to clotrimazole could introduce as good candidates for antimicrobial agents. |
| first_indexed | 2024-03-08T10:13:59Z |
| format | Article |
| id | doaj.art-c4a218339eac4c678a8133e4d81caf11 |
| institution | Directory Open Access Journal |
| issn | 2538-4635 |
| language | English |
| last_indexed | 2024-03-08T10:13:59Z |
| publishDate | 2018-11-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Biology |
| spelling | doaj.art-c4a218339eac4c678a8133e4d81caf112024-01-29T05:58:27ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Biology2538-46352018-11-0133798210.31557/apjcb.2018.3.3.79-82239Cytotoxic Activity of Some Azole DerivativesZeinab Faghih0Zahra Rezaei1Akram Jamshidzade2Aboozar Keshavarz3Soghra Khabnadideh4Pharmaceutical Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Pharmaceutical Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.1 Pharmaceutical Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 2 Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranAzole derivatives are an important class of compounds in medicinal chemistry with a wide variety of biological activities. We previously described synthesis and antimicrobial evaluations of some new Azole derivatives. Most of our compounds showed desirable activity against different species of microorganisms. Here, we chose seventeen of these compounds, in four different groups including imidazole (group a, 1a-6a), 2-methylimidazole (group b, 1b-4b), 2-methyl-4-nitroimidazole (group c, 1c-4c) and benzimidazole (group d, 1d-3d) to further evaluate their cytotoxic activities against a human cancer cell line (HepG2) in comparison to cisplatin using colorimetric MTT cytotoxic assay. We also compared their cytotoxic activities with clotrimazole to find the safer compounds as antimicrobial agents. Our results indicated that Azole compounds including 2b, 4c, 2d and 3d displayed desirable anti-tumor activities against HepG2 (IC50<50μM) and might be considered as potential anticancer agents for further studies. The o her compounds with less cytotoxicity compared to clotrimazole could introduce as good candidates for antimicrobial agents.http://www.waocp.com/journal/index.php/apjcb/article/view/239azole-anti-tumor activity- mtt- hepg2 |
| spellingShingle | Zeinab Faghih Zahra Rezaei Akram Jamshidzade Aboozar Keshavarz Soghra Khabnadideh Cytotoxic Activity of Some Azole Derivatives Asian Pacific Journal of Cancer Biology azole-anti-tumor activity- mtt- hepg2 |
| title | Cytotoxic Activity of Some Azole Derivatives |
| title_full | Cytotoxic Activity of Some Azole Derivatives |
| title_fullStr | Cytotoxic Activity of Some Azole Derivatives |
| title_full_unstemmed | Cytotoxic Activity of Some Azole Derivatives |
| title_short | Cytotoxic Activity of Some Azole Derivatives |
| title_sort | cytotoxic activity of some azole derivatives |
| topic | azole-anti-tumor activity- mtt- hepg2 |
| url | http://www.waocp.com/journal/index.php/apjcb/article/view/239 |
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