Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis

Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis

Diabetes mellitus is a multi-systematic chronic metabolic disorder and life-threatening disease resulting from impaired glucose homeostasis. The inhibition of glucosidase, particularly α-glucosidase, could serve as an effective methodology in treating diabetes. Attributed to the catalytic function o...

Full description

Bibliographic Details
Main Authors: Atteeque Ahmed, Sumera Zaib, Mashooq Ahmad Bhat, Aamer Saeed, Muhammad Zain Altaf, Fatima Tuz Zahra, Ghulam Shabir, Nehal Rana, Imtiaz Khan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Chemistry
Subjects:
alpha glucosidase
diabetes mellitus
pyrazole-clubbed sulfonamides
pharmacokinetics
SeeSAR
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1380523/full

Similar Items

Similar Items