Influenza virus infections among patients attending emergency department according to main reason to presenting to ED: A 3-year prospective observational study during seasonal epidemic periods.
<h4>Objective</h4>The role of influenza virus in patients presenting at ED during seasonal-epidemic periods has not previously been specified. Our objective was to determine its frequency according to clinical presentation.<h4>Methods</h4>This is a prospective observational s...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0182191&type=printable |
| _version_ | 1826530581084635136 |
|---|---|
| author | Enrique Casalino Stephanie Antoniol Nadhira Fidouh Christophe Choquet Jean-Christophe Lucet Xavier Duval Benoit Visseaux Laurent Pereira |
| author_facet | Enrique Casalino Stephanie Antoniol Nadhira Fidouh Christophe Choquet Jean-Christophe Lucet Xavier Duval Benoit Visseaux Laurent Pereira |
| author_sort | Enrique Casalino |
| collection | DOAJ |
| description | <h4>Objective</h4>The role of influenza virus in patients presenting at ED during seasonal-epidemic periods has not previously been specified. Our objective was to determine its frequency according to clinical presentation.<h4>Methods</h4>This is a prospective observational study conducted during three-consecutive seasonal Influenza epidemics (2013-2015), including patients presenting i) community-acquired pneumonia (CAP); ii) severe acute symptoms (SAS): respiratory failure (RF), hemodynamic failure (HF), cardiac failure (CF), and miscellaneous symptoms (M); iii) symptoms suggesting influenza (PSSI). Patients were tested for influenza using specific PCR on naso-pharyngeal swabs.<h4>Results</h4>Of 1,239 patients, virological samples were taken from 784 (63.3%), 213 (27.2%) of whom were positive for the influenza virus: CAP 52/177 (29.4%), SAS 115/447 (25.7%) and PSSI 46/160 (28.8%) (p = 0.6). In the SAS group positivity rates were: RF 76/263 (28.9%), HF 5/29 (17.2%), CF 15/68 (22.1%), and M 19/87 (21.8%) (p = 0.3). Among the major diagnostic categories, the influenza virus positivity rates were: asthma 60/231 (26%), acute exacerbation of chronic obstructive pulmonary disease 18/86 (20.9%), HIV 5/21 (23.8%) and cardiac failure 33/131 (25.2%). The positivity of the samples has not been associated (p>0.1) nor the presence of signs of severity or admission rate in medical ward nor intensive care unit.<h4>Conclusions</h4>Our results indicate that during seasonal influenza epidemics, Influenza virus-positivity rate is similar in patients attending ED for influenza-compatible clinical features, patients with acute symptoms including pneumonia, respiratory, hemodynamic and cardiac distress, and patients presenting for acute decompensation of chronic respiratory and cardiac diseases. |
| first_indexed | 2024-12-17T03:46:59Z |
| format | Article |
| id | doaj.art-c4a5cd73c4cf45ddba23cffebede49c0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-14T01:21:43Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c4a5cd73c4cf45ddba23cffebede49c02025-03-13T05:31:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018219110.1371/journal.pone.0182191Influenza virus infections among patients attending emergency department according to main reason to presenting to ED: A 3-year prospective observational study during seasonal epidemic periods.Enrique CasalinoStephanie AntoniolNadhira FidouhChristophe ChoquetJean-Christophe LucetXavier DuvalBenoit VisseauxLaurent Pereira<h4>Objective</h4>The role of influenza virus in patients presenting at ED during seasonal-epidemic periods has not previously been specified. Our objective was to determine its frequency according to clinical presentation.<h4>Methods</h4>This is a prospective observational study conducted during three-consecutive seasonal Influenza epidemics (2013-2015), including patients presenting i) community-acquired pneumonia (CAP); ii) severe acute symptoms (SAS): respiratory failure (RF), hemodynamic failure (HF), cardiac failure (CF), and miscellaneous symptoms (M); iii) symptoms suggesting influenza (PSSI). Patients were tested for influenza using specific PCR on naso-pharyngeal swabs.<h4>Results</h4>Of 1,239 patients, virological samples were taken from 784 (63.3%), 213 (27.2%) of whom were positive for the influenza virus: CAP 52/177 (29.4%), SAS 115/447 (25.7%) and PSSI 46/160 (28.8%) (p = 0.6). In the SAS group positivity rates were: RF 76/263 (28.9%), HF 5/29 (17.2%), CF 15/68 (22.1%), and M 19/87 (21.8%) (p = 0.3). Among the major diagnostic categories, the influenza virus positivity rates were: asthma 60/231 (26%), acute exacerbation of chronic obstructive pulmonary disease 18/86 (20.9%), HIV 5/21 (23.8%) and cardiac failure 33/131 (25.2%). The positivity of the samples has not been associated (p>0.1) nor the presence of signs of severity or admission rate in medical ward nor intensive care unit.<h4>Conclusions</h4>Our results indicate that during seasonal influenza epidemics, Influenza virus-positivity rate is similar in patients attending ED for influenza-compatible clinical features, patients with acute symptoms including pneumonia, respiratory, hemodynamic and cardiac distress, and patients presenting for acute decompensation of chronic respiratory and cardiac diseases.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0182191&type=printable |
| spellingShingle | Enrique Casalino Stephanie Antoniol Nadhira Fidouh Christophe Choquet Jean-Christophe Lucet Xavier Duval Benoit Visseaux Laurent Pereira Influenza virus infections among patients attending emergency department according to main reason to presenting to ED: A 3-year prospective observational study during seasonal epidemic periods. PLoS ONE |
| title | Influenza virus infections among patients attending emergency department according to main reason to presenting to ED: A 3-year prospective observational study during seasonal epidemic periods. |
| title_full | Influenza virus infections among patients attending emergency department according to main reason to presenting to ED: A 3-year prospective observational study during seasonal epidemic periods. |
| title_fullStr | Influenza virus infections among patients attending emergency department according to main reason to presenting to ED: A 3-year prospective observational study during seasonal epidemic periods. |
| title_full_unstemmed | Influenza virus infections among patients attending emergency department according to main reason to presenting to ED: A 3-year prospective observational study during seasonal epidemic periods. |
| title_short | Influenza virus infections among patients attending emergency department according to main reason to presenting to ED: A 3-year prospective observational study during seasonal epidemic periods. |
| title_sort | influenza virus infections among patients attending emergency department according to main reason to presenting to ed a 3 year prospective observational study during seasonal epidemic periods |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0182191&type=printable |
| work_keys_str_mv | AT enriquecasalino influenzavirusinfectionsamongpatientsattendingemergencydepartmentaccordingtomainreasontopresentingtoeda3yearprospectiveobservationalstudyduringseasonalepidemicperiods AT stephanieantoniol influenzavirusinfectionsamongpatientsattendingemergencydepartmentaccordingtomainreasontopresentingtoeda3yearprospectiveobservationalstudyduringseasonalepidemicperiods AT nadhirafidouh influenzavirusinfectionsamongpatientsattendingemergencydepartmentaccordingtomainreasontopresentingtoeda3yearprospectiveobservationalstudyduringseasonalepidemicperiods AT christophechoquet influenzavirusinfectionsamongpatientsattendingemergencydepartmentaccordingtomainreasontopresentingtoeda3yearprospectiveobservationalstudyduringseasonalepidemicperiods AT jeanchristophelucet influenzavirusinfectionsamongpatientsattendingemergencydepartmentaccordingtomainreasontopresentingtoeda3yearprospectiveobservationalstudyduringseasonalepidemicperiods AT xavierduval influenzavirusinfectionsamongpatientsattendingemergencydepartmentaccordingtomainreasontopresentingtoeda3yearprospectiveobservationalstudyduringseasonalepidemicperiods AT benoitvisseaux influenzavirusinfectionsamongpatientsattendingemergencydepartmentaccordingtomainreasontopresentingtoeda3yearprospectiveobservationalstudyduringseasonalepidemicperiods AT laurentpereira influenzavirusinfectionsamongpatientsattendingemergencydepartmentaccordingtomainreasontopresentingtoeda3yearprospectiveobservationalstudyduringseasonalepidemicperiods |