Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study
(1) Background: To investigate the association between plasma fatty acids (FAs) and dry eye disease (DED) in an elderly population; (2) Methods: We conducted a population-based study, the Montrachet study, in individuals older than 75 years. DED was evaluated using the Schirmer I test without anesth...
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MDPI AG
2022-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/11/2290 |
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| author | Alassane Seydou Louis Arnould Pierre-Henry Gabrielle Florian Baudin Ines Ben Ghezala Alain M. Bron Niyazi Acar Catherine Creuzot-Garcher |
| author_facet | Alassane Seydou Louis Arnould Pierre-Henry Gabrielle Florian Baudin Ines Ben Ghezala Alain M. Bron Niyazi Acar Catherine Creuzot-Garcher |
| author_sort | Alassane Seydou |
| collection | DOAJ |
| description | (1) Background: To investigate the association between plasma fatty acids (FAs) and dry eye disease (DED) in an elderly population; (2) Methods: We conducted a population-based study, the Montrachet study, in individuals older than 75 years. DED was evaluated using the Schirmer I test without anesthesia, tear film breakup time (TFBUT) measurement and fluorescein corneal staining. Plasma FAs were measured in fasting blood using gas chromatography; (3) Results: A total of 740 subjects with a plasma measurement of 25 FAs were included in this study. The mean age was 82.2 ± 3.7 years, and 62.7% were women. DED was present in 35.0% of participants. We identified a plasma FAs pattern positively associated with DED, characterized by low polyunsaturated fatty acids (PUFAs), high monounsaturated fatty acids (MUFAs) and low saturated fatty acids (SFAs) levels. After adjustment for major confounders, individuals in the upper quartile of the FAs pattern scores compared with those in the lower quartile were more likely to present DED (OR 2.46 (95% CI 1.51–4.01), <i>p</i> = 0.001); (4) Conclusion: In this study, we found that a plasma FAs pattern characterized by low PUFAs, high MUFAs and low SFAs was significantly associated with DED in elderly participants. |
| first_indexed | 2024-03-10T01:00:00Z |
| format | Article |
| id | doaj.art-c4a6dac8106b46e395ec53087382548f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:00:00Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c4a6dac8106b46e395ec53087382548f2023-11-23T14:36:40ZengMDPI AGNutrients2072-66432022-05-011411229010.3390/nu14112290Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based StudyAlassane Seydou0Louis Arnould1Pierre-Henry Gabrielle2Florian Baudin3Ines Ben Ghezala4Alain M. Bron5Niyazi Acar6Catherine Creuzot-Garcher7Ophthalmology Department, Dijon University Hospital, 21000 Dijon, FranceOphthalmology Department, Dijon University Hospital, 21000 Dijon, FranceOphthalmology Department, Dijon University Hospital, 21000 Dijon, FranceOphthalmology Department, Dijon University Hospital, 21000 Dijon, FranceOphthalmology Department, Dijon University Hospital, 21000 Dijon, FranceOphthalmology Department, Dijon University Hospital, 21000 Dijon, FranceCentre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, 21000 Dijon, FranceOphthalmology Department, Dijon University Hospital, 21000 Dijon, France(1) Background: To investigate the association between plasma fatty acids (FAs) and dry eye disease (DED) in an elderly population; (2) Methods: We conducted a population-based study, the Montrachet study, in individuals older than 75 years. DED was evaluated using the Schirmer I test without anesthesia, tear film breakup time (TFBUT) measurement and fluorescein corneal staining. Plasma FAs were measured in fasting blood using gas chromatography; (3) Results: A total of 740 subjects with a plasma measurement of 25 FAs were included in this study. The mean age was 82.2 ± 3.7 years, and 62.7% were women. DED was present in 35.0% of participants. We identified a plasma FAs pattern positively associated with DED, characterized by low polyunsaturated fatty acids (PUFAs), high monounsaturated fatty acids (MUFAs) and low saturated fatty acids (SFAs) levels. After adjustment for major confounders, individuals in the upper quartile of the FAs pattern scores compared with those in the lower quartile were more likely to present DED (OR 2.46 (95% CI 1.51–4.01), <i>p</i> = 0.001); (4) Conclusion: In this study, we found that a plasma FAs pattern characterized by low PUFAs, high MUFAs and low SFAs was significantly associated with DED in elderly participants.https://www.mdpi.com/2072-6643/14/11/2290dry eye diseaseelderlyepidemiologyfatty acids patternlipidspopulation-based study |
| spellingShingle | Alassane Seydou Louis Arnould Pierre-Henry Gabrielle Florian Baudin Ines Ben Ghezala Alain M. Bron Niyazi Acar Catherine Creuzot-Garcher Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study Nutrients dry eye disease elderly epidemiology fatty acids pattern lipids population-based study |
| title | Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study |
| title_full | Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study |
| title_fullStr | Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study |
| title_full_unstemmed | Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study |
| title_short | Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study |
| title_sort | plasma fatty acids pattern and dry eye disease in the elderly the montrachet population based study |
| topic | dry eye disease elderly epidemiology fatty acids pattern lipids population-based study |
| url | https://www.mdpi.com/2072-6643/14/11/2290 |
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