Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation

Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation

Abstract Background Although most patients with diffuse large B-cell lymphoma (DLBCL) achieve complete remission after first-line rituximab-containing immunochemotherapy, up to 40% of patients relapse and require salvage therapy. Among those patients, a substantial proportion remain refractory to sa...

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Bibliographic Details
Main Authors: Jun Liu, Suji Min, Dongchan Kim, Jihyun Park, Eunchae Park, Youngil Koh, Dong-Yeop Shin, Tae Kon Kim, Ja Min Byun, Sung-Soo Yoon, Junshik Hong
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Clinical Epigenetics
Subjects:
DLBCL
5-Azacytidine
ERVs
STING
Cisplatin
Online Access:https://doi.org/10.1186/s13148-023-01493-x

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