Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation

Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation

Abstract Background Although most patients with diffuse large B-cell lymphoma (DLBCL) achieve complete remission after first-line rituximab-containing immunochemotherapy, up to 40% of patients relapse and require salvage therapy. Among those patients, a substantial proportion remain refractory to sa...

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Podrobná bibliografie
Hlavní autoři: Jun Liu, Suji Min, Dongchan Kim, Jihyun Park, Eunchae Park, Youngil Koh, Dong-Yeop Shin, Tae Kon Kim, Ja Min Byun, Sung-Soo Yoon, Junshik Hong
Médium: Článek
Jazyk:English
Vydáno: BMC 2023-05-01
Edice:Clinical Epigenetics
Témata:
DLBCL
5-Azacytidine
ERVs
STING
Cisplatin
On-line přístup:https://doi.org/10.1186/s13148-023-01493-x

Internet

https://doi.org/10.1186/s13148-023-01493-x

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