Abdominal perfusion in canine patients with pyometra and sepsis evaluated by Doppler and contrast-enhanced ultrasound
Abstract Background Sepsis is a condition characterized by organic dysfunction, leading to hemodynamic instability and high morbidity and mortality rates in humans and animals. Early identification of perfusion changes and appropriate management of sepsis are crucial for improving patient prognosis....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12917-023-03747-5 |
| _version_ | 1797559047095844864 |
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| author | Beatriz Gasser Ricardo Andres Ramirez Uscategui Luiz Paulo Nogueira Aires Diego Iwao Yamada Priscila Del’Aguila-Silva Bruna Bressianini Lima Priscila Silva Igor Cezar Kniphoff da Cruz Rafael Kretzer Carneiro Marcus Antônio Rossi Feliciano |
| author_facet | Beatriz Gasser Ricardo Andres Ramirez Uscategui Luiz Paulo Nogueira Aires Diego Iwao Yamada Priscila Del’Aguila-Silva Bruna Bressianini Lima Priscila Silva Igor Cezar Kniphoff da Cruz Rafael Kretzer Carneiro Marcus Antônio Rossi Feliciano |
| author_sort | Beatriz Gasser |
| collection | DOAJ |
| description | Abstract Background Sepsis is a condition characterized by organic dysfunction, leading to hemodynamic instability and high morbidity and mortality rates in humans and animals. Early identification of perfusion changes and appropriate management of sepsis are crucial for improving patient prognosis. Currently, the Systemic Inflammatory Response Syndrome (SIRS) and Sequential Organ Failure Assessment (SOFA) scores are widely studied for sepsis identification and evaluation of organ dysfunction. However, these scores do not assess gastrointestinal involvement, which is common in this condition. Contrast-enhanced ultrasound (CEUS) and Doppler have been considered promising diagnostic techniques for detecting changes in vascularization and microcirculation in a non-invasive and safe manner, particularly in the gastrointestinal system. This study aimed to evaluate duodenal perfusion using CEUS, as well as abdominal aortic and cranial mesenteric artery blood flow using Doppler ultrasound, and systolic arterial pressure (SAP) in 17 bitches with pyometra and in 10 healthy animals. Results The variables were compared between the pyometra and control groups, as well between patients with and without sepsis determined by the SOFA or SIRS scores. Pyometra was found to cause a reduction in abdominal aortic blood flow volume, aortic peak systolic velocity, and resistivity index as evaluated by Doppler ultrasound. Patients with sepsis according to the SOFA criteria only presented lower SAP. In contrast, sepsis animals identified by the SIRS score exhibited lower SAP, aortic peak systolic velocity, aortic blood flow volume, and aortic resistivity index and additionally, higher peak intensity of contrast in the duodenal wall. Conclusions Pyometra causes a reduction in abdominal aortic blood flow, which is more pronounced in animals with sepsis identified by the SIRS criteria. These animals also exhibited a decrease in systolic blood pressure and an increase in duodenal perfusion, as evident by CEUS. However, these changes were not observed in patients with sepsis identified by the SOFA criteria. The alterations in intestinal perfusion observed in animals with sepsis indicate the presence of inflammation or dysfunction. In this regard, CEUS proves to be a valuable technique for detecting subtle changes in tissue hemodynamics that may not be apparent in conventional exams. |
| first_indexed | 2024-03-10T17:40:11Z |
| format | Article |
| id | doaj.art-c4a8b3e1e7f74fcf9d4fc2534d555e4d |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-03-10T17:40:11Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-c4a8b3e1e7f74fcf9d4fc2534d555e4d2023-11-20T09:44:57ZengBMCBMC Veterinary Research1746-61482023-09-011911910.1186/s12917-023-03747-5Abdominal perfusion in canine patients with pyometra and sepsis evaluated by Doppler and contrast-enhanced ultrasoundBeatriz Gasser0Ricardo Andres Ramirez Uscategui1Luiz Paulo Nogueira Aires2Diego Iwao Yamada3Priscila Del’Aguila-Silva4Bruna Bressianini Lima5Priscila Silva6Igor Cezar Kniphoff da Cruz7Rafael Kretzer Carneiro8Marcus Antônio Rossi Feliciano9Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual PaulistaFacultad de Medicina Veterinaria y Zootecnia, Universidad del TolimaFaculdade de Ciências Agrárias e Veterinárias, Universidade Estadual PaulistaUniversidade de MaríliaFaculdade de Ciências Agrárias e Veterinárias, Universidade Estadual PaulistaFaculdade de Ciências Agrárias e Veterinárias, Universidade Estadual PaulistaFaculdade de Ciências Agrárias e Veterinárias, Universidade Estadual PaulistaCentro de Ciências Rurais, Universidade Federal de Santa MariaUniversidade do Estado de Santa CatarinaFaculdade de Zootecnia e Engenharia de Alimentos, Universidade de São PauloAbstract Background Sepsis is a condition characterized by organic dysfunction, leading to hemodynamic instability and high morbidity and mortality rates in humans and animals. Early identification of perfusion changes and appropriate management of sepsis are crucial for improving patient prognosis. Currently, the Systemic Inflammatory Response Syndrome (SIRS) and Sequential Organ Failure Assessment (SOFA) scores are widely studied for sepsis identification and evaluation of organ dysfunction. However, these scores do not assess gastrointestinal involvement, which is common in this condition. Contrast-enhanced ultrasound (CEUS) and Doppler have been considered promising diagnostic techniques for detecting changes in vascularization and microcirculation in a non-invasive and safe manner, particularly in the gastrointestinal system. This study aimed to evaluate duodenal perfusion using CEUS, as well as abdominal aortic and cranial mesenteric artery blood flow using Doppler ultrasound, and systolic arterial pressure (SAP) in 17 bitches with pyometra and in 10 healthy animals. Results The variables were compared between the pyometra and control groups, as well between patients with and without sepsis determined by the SOFA or SIRS scores. Pyometra was found to cause a reduction in abdominal aortic blood flow volume, aortic peak systolic velocity, and resistivity index as evaluated by Doppler ultrasound. Patients with sepsis according to the SOFA criteria only presented lower SAP. In contrast, sepsis animals identified by the SIRS score exhibited lower SAP, aortic peak systolic velocity, aortic blood flow volume, and aortic resistivity index and additionally, higher peak intensity of contrast in the duodenal wall. Conclusions Pyometra causes a reduction in abdominal aortic blood flow, which is more pronounced in animals with sepsis identified by the SIRS criteria. These animals also exhibited a decrease in systolic blood pressure and an increase in duodenal perfusion, as evident by CEUS. However, these changes were not observed in patients with sepsis identified by the SOFA criteria. The alterations in intestinal perfusion observed in animals with sepsis indicate the presence of inflammation or dysfunction. In this regard, CEUS proves to be a valuable technique for detecting subtle changes in tissue hemodynamics that may not be apparent in conventional exams.https://doi.org/10.1186/s12917-023-03747-5Blood flowIntestinal hemodynamicCEUSSIRSSOFAInfection |
| spellingShingle | Beatriz Gasser Ricardo Andres Ramirez Uscategui Luiz Paulo Nogueira Aires Diego Iwao Yamada Priscila Del’Aguila-Silva Bruna Bressianini Lima Priscila Silva Igor Cezar Kniphoff da Cruz Rafael Kretzer Carneiro Marcus Antônio Rossi Feliciano Abdominal perfusion in canine patients with pyometra and sepsis evaluated by Doppler and contrast-enhanced ultrasound BMC Veterinary Research Blood flow Intestinal hemodynamic CEUS SIRS SOFA Infection |
| title | Abdominal perfusion in canine patients with pyometra and sepsis evaluated by Doppler and contrast-enhanced ultrasound |
| title_full | Abdominal perfusion in canine patients with pyometra and sepsis evaluated by Doppler and contrast-enhanced ultrasound |
| title_fullStr | Abdominal perfusion in canine patients with pyometra and sepsis evaluated by Doppler and contrast-enhanced ultrasound |
| title_full_unstemmed | Abdominal perfusion in canine patients with pyometra and sepsis evaluated by Doppler and contrast-enhanced ultrasound |
| title_short | Abdominal perfusion in canine patients with pyometra and sepsis evaluated by Doppler and contrast-enhanced ultrasound |
| title_sort | abdominal perfusion in canine patients with pyometra and sepsis evaluated by doppler and contrast enhanced ultrasound |
| topic | Blood flow Intestinal hemodynamic CEUS SIRS SOFA Infection |
| url | https://doi.org/10.1186/s12917-023-03747-5 |
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