Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater
The sphingolipid sphingosine-1-phosphate (S1P) is produced by sphingosine kinases to either signal through intracellular targets or to activate a family of specific G-protein-coupled receptors (S1PR). S1P levels are usually low in peripheral tissues compared to the vasculature, forming a gradient th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01706/full |
| _version_ | 1811315987422642176 |
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| author | Andreas Weigert Catherine Olesch Bernhard Brüne Bernhard Brüne Bernhard Brüne Bernhard Brüne |
| author_facet | Andreas Weigert Catherine Olesch Bernhard Brüne Bernhard Brüne Bernhard Brüne Bernhard Brüne |
| author_sort | Andreas Weigert |
| collection | DOAJ |
| description | The sphingolipid sphingosine-1-phosphate (S1P) is produced by sphingosine kinases to either signal through intracellular targets or to activate a family of specific G-protein-coupled receptors (S1PR). S1P levels are usually low in peripheral tissues compared to the vasculature, forming a gradient that mediates lymphocyte trafficking. However, S1P levels rise during inflammation in peripheral tissues, thereby affecting resident or recruited immune cells, including macrophages. As macrophages orchestrate initiation and resolution of inflammation, the sphingosine kinase/S1P/S1P-receptor axis emerges as an important determinant of macrophage function in the pathogenesis of inflammatory diseases such as cancer, atherosclerosis, and infection. In this review, we therefore summarize the current knowledge how S1P affects macrophage biology. |
| first_indexed | 2024-04-13T11:40:58Z |
| format | Article |
| id | doaj.art-c4a967ccc67e482f83e5ee233ba2d94b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T11:40:58Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c4a967ccc67e482f83e5ee233ba2d94b2022-12-22T02:48:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-07-011010.3389/fimmu.2019.01706469023Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big EaterAndreas Weigert0Catherine Olesch1Bernhard Brüne2Bernhard Brüne3Bernhard Brüne4Bernhard Brüne5Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, GermanyFaculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, GermanyFaculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, GermanyGerman Cancer Consortium (DKTK), Partner Site Frankfurt, Frankfurt, GermanyProject Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology, Frankfurt, GermanyFrankfurt Cancer Institute, Goethe-University Frankfurt, Frankfurt, GermanyThe sphingolipid sphingosine-1-phosphate (S1P) is produced by sphingosine kinases to either signal through intracellular targets or to activate a family of specific G-protein-coupled receptors (S1PR). S1P levels are usually low in peripheral tissues compared to the vasculature, forming a gradient that mediates lymphocyte trafficking. However, S1P levels rise during inflammation in peripheral tissues, thereby affecting resident or recruited immune cells, including macrophages. As macrophages orchestrate initiation and resolution of inflammation, the sphingosine kinase/S1P/S1P-receptor axis emerges as an important determinant of macrophage function in the pathogenesis of inflammatory diseases such as cancer, atherosclerosis, and infection. In this review, we therefore summarize the current knowledge how S1P affects macrophage biology.https://www.frontiersin.org/article/10.3389/fimmu.2019.01706/fullsphingosine-1-phosphatemacrophagesmacrophage polarizationcanceratherosclerosisinfection |
| spellingShingle | Andreas Weigert Catherine Olesch Bernhard Brüne Bernhard Brüne Bernhard Brüne Bernhard Brüne Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater Frontiers in Immunology sphingosine-1-phosphate macrophages macrophage polarization cancer atherosclerosis infection |
| title | Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater |
| title_full | Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater |
| title_fullStr | Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater |
| title_full_unstemmed | Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater |
| title_short | Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater |
| title_sort | sphingosine 1 phosphate and macrophage biology how the sphinx tames the big eater |
| topic | sphingosine-1-phosphate macrophages macrophage polarization cancer atherosclerosis infection |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01706/full |
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