Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila

Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila

Abstract Background The anticancer drug camptothecin (CPT), first isolated from Camptotheca acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila. Unlike known monoterpene indole alkaloids, CPT in C. acuminata is biosynthesized via the key intermediate strictosidin...

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Bibliographic Details
Main Authors: Mengquan Yang, Qiang Wang, Yining Liu, Xiaolong Hao, Can Wang, Yuchen Liang, Jianbo Chen, Youli Xiao, Guoyin Kai
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Biology
Subjects:
Biosynthesis
Camptothecin
In vivo labelling
Ophiorrhiza pumila
Strictosidine
Online Access:https://doi.org/10.1186/s12915-021-01051-y

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