Upregulated ribosome pathway plays a key role in HDAC4, improving the survival rate and biofunction of chondrocytes

Upregulated ribosome pathway plays a key role in HDAC4, improving the survival rate and biofunction of chondrocytes

Aims: To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis. Methods: Empty adenovirus (EP) and a HDAC4 overexpression adenovirus were transfected into cultured human chondrocytes. The cell survival rate was examined by real-...

Full description

Bibliographic Details
Main Authors: Li Guo, Hua Guo, Yuanyu Zhang, Zhi Chen, Jian Sun, Gaige Wu, Yunfei Wang, Yang Zhang, Xiaochun Wei, Pengcui Li
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2023-07-01
Series:Bone & Joint Research
Subjects:
histone deacetylase 4
rna sequencing
ribosome
chondrocyte
gene mutation
chondrocytes
rnas
western blotting
mrnas
gene expression
flow cytometry
quantitative polymerase chain reaction
cartilage tissues
rat models
apoptosis
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.127.BJR-2022-0279.R2

Similar Items

Similar Items