Protective Effects of Vitamin D3 on Male Rat’s Hepatic Cell Injured by Diclofenac, A Histopathological Study
This experiment aimed to study the protective effects of vitamin D3 on hepatic cells injured by Diclofenac. Twenty-one male rats, 8 to 12 weeks of age and in weight from 180 to 220 grams, were housed in a standard, pathogen-free environment in the “College of Veterinary Medicine, University...
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| Format: | Article |
| Language: | Arabic |
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College of Veterinary Medicine, University of Fallujah
2022-12-01
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| Series: | مجلة الانبار للعلوم البيطرية |
| Online Access: | https://www.anbarjvs.edu.iq/protective-effects-of-vitamin-d3-on-male-rats-hepatic-cell-injured-by-diclofenac-a-histopathological-study/ |
| _version_ | 1811197379484844032 |
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| author | Ali A. Tala’a |
| author_facet | Ali A. Tala’a |
| author_sort | Ali A. Tala’a |
| collection | DOAJ |
| description | This experiment aimed to study the protective effects of vitamin D3 on hepatic cells injured by Diclofenac. Twenty-one male rats, 8 to 12 weeks of age and in weight from 180 to 220 grams, were housed in a standard, pathogen-free environment in the “College of Veterinary Medicine, University of Fallujah,” given unrestricted access to standard rat water and food. Then the rats were divided into 3 groups (each group containing 7 rats): G1 control group (IM injection of distill water for 7 days), G2 Diclofenac only (7-day course of a 10 mg/kg IM injection of diclofenac), G3 received intramuscular injections of VD3 three times per week at a dose of 1000 IU/Kg, then a 7-day course of a 10 mg/kg IM injection of diclofenac. Liver histological sections of the normal control (G1) showed no histopathological changes, while the histopathological sections of the liver of G2 exhibit hydropic degeneration, blood vessels congestion and inflammatory cell infiltration, Liver sections of G3 presented blood vessels congestion and mild inflammatory cell infiltration. This study concluded that VD3 can decrease the liver damage caused by diclofenac |
| first_indexed | 2024-04-12T01:12:30Z |
| format | Article |
| id | doaj.art-c4ac5dfc89bd4975ab5b872ff18b4ea5 |
| institution | Directory Open Access Journal |
| issn | 1999-6527 2707-0603 |
| language | Arabic |
| last_indexed | 2024-04-12T01:12:30Z |
| publishDate | 2022-12-01 |
| publisher | College of Veterinary Medicine, University of Fallujah |
| record_format | Article |
| series | مجلة الانبار للعلوم البيطرية |
| spelling | doaj.art-c4ac5dfc89bd4975ab5b872ff18b4ea52022-12-22T03:54:03ZaraCollege of Veterinary Medicine, University of Fallujahمجلة الانبار للعلوم البيطرية1999-65272707-06032022-12-011529710310.37940/AJVS.2022.15.2.10Protective Effects of Vitamin D3 on Male Rat’s Hepatic Cell Injured by Diclofenac, A Histopathological StudyAli A. Tala’a This experiment aimed to study the protective effects of vitamin D3 on hepatic cells injured by Diclofenac. Twenty-one male rats, 8 to 12 weeks of age and in weight from 180 to 220 grams, were housed in a standard, pathogen-free environment in the “College of Veterinary Medicine, University of Fallujah,” given unrestricted access to standard rat water and food. Then the rats were divided into 3 groups (each group containing 7 rats): G1 control group (IM injection of distill water for 7 days), G2 Diclofenac only (7-day course of a 10 mg/kg IM injection of diclofenac), G3 received intramuscular injections of VD3 three times per week at a dose of 1000 IU/Kg, then a 7-day course of a 10 mg/kg IM injection of diclofenac. Liver histological sections of the normal control (G1) showed no histopathological changes, while the histopathological sections of the liver of G2 exhibit hydropic degeneration, blood vessels congestion and inflammatory cell infiltration, Liver sections of G3 presented blood vessels congestion and mild inflammatory cell infiltration. This study concluded that VD3 can decrease the liver damage caused by diclofenachttps://www.anbarjvs.edu.iq/protective-effects-of-vitamin-d3-on-male-rats-hepatic-cell-injured-by-diclofenac-a-histopathological-study/ |
| spellingShingle | Ali A. Tala’a Protective Effects of Vitamin D3 on Male Rat’s Hepatic Cell Injured by Diclofenac, A Histopathological Study مجلة الانبار للعلوم البيطرية |
| title | Protective Effects of Vitamin D3 on Male Rat’s Hepatic Cell Injured by Diclofenac, A Histopathological Study |
| title_full | Protective Effects of Vitamin D3 on Male Rat’s Hepatic Cell Injured by Diclofenac, A Histopathological Study |
| title_fullStr | Protective Effects of Vitamin D3 on Male Rat’s Hepatic Cell Injured by Diclofenac, A Histopathological Study |
| title_full_unstemmed | Protective Effects of Vitamin D3 on Male Rat’s Hepatic Cell Injured by Diclofenac, A Histopathological Study |
| title_short | Protective Effects of Vitamin D3 on Male Rat’s Hepatic Cell Injured by Diclofenac, A Histopathological Study |
| title_sort | protective effects of vitamin d3 on male rat s hepatic cell injured by diclofenac a histopathological study |
| url | https://www.anbarjvs.edu.iq/protective-effects-of-vitamin-d3-on-male-rats-hepatic-cell-injured-by-diclofenac-a-histopathological-study/ |
| work_keys_str_mv | AT aliatalaa protectiveeffectsofvitamind3onmaleratshepaticcellinjuredbydiclofenacahistopathologicalstudy |