Enhanced In Vitro Biocompatible Polycaprolactone/Nano-Hydroxyapatite Scaffolds with Near-Field Direct-Writing Melt Electrospinning Technology
Polycaprolactone (PCL) scaffold is a common biological material for tissue engineering, owing to its good biocompatibility, biodegradability and plasticity. However, it is not suitable for osteoblast adhesion and regeneration of bone tissue due to its non-biological activity, poor mechanical strengt...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/161 |
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| author | Zhijun Chen Yanbo Liu Juan Huang Han Wang Ming Hao Xiaodong Hu Xiaoming Qian Jintu Fan Hongjun Yang Bo Yang |
| author_facet | Zhijun Chen Yanbo Liu Juan Huang Han Wang Ming Hao Xiaodong Hu Xiaoming Qian Jintu Fan Hongjun Yang Bo Yang |
| author_sort | Zhijun Chen |
| collection | DOAJ |
| description | Polycaprolactone (PCL) scaffold is a common biological material for tissue engineering, owing to its good biocompatibility, biodegradability and plasticity. However, it is not suitable for osteoblast adhesion and regeneration of bone tissue due to its non-biological activity, poor mechanical strength, slow degradation speed, smooth surface and strong hydrophobicity. To improve the mechanical properties and biocompatibility of PCL scaffold, the PCL/nHA scaffolds were prepared by melting and blending different proportions of nano-hydroxyapatite (nHA) with PCL by the near-field direct-writing melt electrospinning technology in this study. The morphology, porosity, mechanical properties and in vitro biocompatibility of the PCL/nHA scaffolds were studied. The results showed that when the proportion of nHA was less than or equal to 25%, PCL/nHA composite scaffolds were easily formed in which bone marrow mesenchymal stem cells proliferated successfully. When the proportion of nHA was 15%, the PCL/nHA composite scaffolds had excellent structural regularity, good fiber uniformity, outstanding mechanical stability and superior biocompatibility. The PCL/nHA composite scaffolds were ideal scaffold materials, which would broaden their applications for bone tissue engineering. |
| first_indexed | 2024-03-09T16:16:09Z |
| format | Article |
| id | doaj.art-c4ae3e819a0344dc80098126077950d8 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:16:09Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-c4ae3e819a0344dc80098126077950d82023-11-24T15:48:40ZengMDPI AGJournal of Functional Biomaterials2079-49832022-09-0113416110.3390/jfb13040161Enhanced In Vitro Biocompatible Polycaprolactone/Nano-Hydroxyapatite Scaffolds with Near-Field Direct-Writing Melt Electrospinning TechnologyZhijun Chen0Yanbo Liu1Juan Huang2Han Wang3Ming Hao4Xiaodong Hu5Xiaoming Qian6Jintu Fan7Hongjun Yang8Bo Yang9State Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, ChinaState Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, ChinaState Key Laboratory of New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, ChinaSchool of Materials Science and Engineering, Wuhan Textile University, Wuhan 430200, ChinaState Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, ChinaState Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, ChinaState Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, ChinaState Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, ChinaSchool of Materials Science and Engineering, Wuhan Textile University, Wuhan 430200, ChinaState Key Laboratory of New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, ChinaPolycaprolactone (PCL) scaffold is a common biological material for tissue engineering, owing to its good biocompatibility, biodegradability and plasticity. However, it is not suitable for osteoblast adhesion and regeneration of bone tissue due to its non-biological activity, poor mechanical strength, slow degradation speed, smooth surface and strong hydrophobicity. To improve the mechanical properties and biocompatibility of PCL scaffold, the PCL/nHA scaffolds were prepared by melting and blending different proportions of nano-hydroxyapatite (nHA) with PCL by the near-field direct-writing melt electrospinning technology in this study. The morphology, porosity, mechanical properties and in vitro biocompatibility of the PCL/nHA scaffolds were studied. The results showed that when the proportion of nHA was less than or equal to 25%, PCL/nHA composite scaffolds were easily formed in which bone marrow mesenchymal stem cells proliferated successfully. When the proportion of nHA was 15%, the PCL/nHA composite scaffolds had excellent structural regularity, good fiber uniformity, outstanding mechanical stability and superior biocompatibility. The PCL/nHA composite scaffolds were ideal scaffold materials, which would broaden their applications for bone tissue engineering.https://www.mdpi.com/2079-4983/13/4/161melt electrospinningnear-field direct-writingcomposite scaffoldsbiocompatibility |
| spellingShingle | Zhijun Chen Yanbo Liu Juan Huang Han Wang Ming Hao Xiaodong Hu Xiaoming Qian Jintu Fan Hongjun Yang Bo Yang Enhanced In Vitro Biocompatible Polycaprolactone/Nano-Hydroxyapatite Scaffolds with Near-Field Direct-Writing Melt Electrospinning Technology Journal of Functional Biomaterials melt electrospinning near-field direct-writing composite scaffolds biocompatibility |
| title | Enhanced In Vitro Biocompatible Polycaprolactone/Nano-Hydroxyapatite Scaffolds with Near-Field Direct-Writing Melt Electrospinning Technology |
| title_full | Enhanced In Vitro Biocompatible Polycaprolactone/Nano-Hydroxyapatite Scaffolds with Near-Field Direct-Writing Melt Electrospinning Technology |
| title_fullStr | Enhanced In Vitro Biocompatible Polycaprolactone/Nano-Hydroxyapatite Scaffolds with Near-Field Direct-Writing Melt Electrospinning Technology |
| title_full_unstemmed | Enhanced In Vitro Biocompatible Polycaprolactone/Nano-Hydroxyapatite Scaffolds with Near-Field Direct-Writing Melt Electrospinning Technology |
| title_short | Enhanced In Vitro Biocompatible Polycaprolactone/Nano-Hydroxyapatite Scaffolds with Near-Field Direct-Writing Melt Electrospinning Technology |
| title_sort | enhanced in vitro biocompatible polycaprolactone nano hydroxyapatite scaffolds with near field direct writing melt electrospinning technology |
| topic | melt electrospinning near-field direct-writing composite scaffolds biocompatibility |
| url | https://www.mdpi.com/2079-4983/13/4/161 |
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