Cerebral Venous Thrombosis: A Challenging Diagnosis; A New Nonenhanced Computed Tomography Standardized Semi-Quantitative Method
Cerebral venous sinus thrombosis (CVST) on non-contrast CT (NCCT) is often challenging to detect. We retrospectively selected 41 children and 36 adults with confirmed CVST and two age-matched control groups with comparable initial symptoms. We evaluated NCCT placing four small circular ROIs in stand...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Tomography |
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| Online Access: | https://www.mdpi.com/2379-139X/8/1/1 |
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| author | Andrea Romano Maria Camilla Rossi-Espagnet Luca Pasquini Alberto Di Napoli Francesco Dellepiane Giulia Butera Giulia Moltoni Olga Gagliardo Alessandro Bozzao |
| author_facet | Andrea Romano Maria Camilla Rossi-Espagnet Luca Pasquini Alberto Di Napoli Francesco Dellepiane Giulia Butera Giulia Moltoni Olga Gagliardo Alessandro Bozzao |
| author_sort | Andrea Romano |
| collection | DOAJ |
| description | Cerebral venous sinus thrombosis (CVST) on non-contrast CT (NCCT) is often challenging to detect. We retrospectively selected 41 children and 36 adults with confirmed CVST and two age-matched control groups with comparable initial symptoms. We evaluated NCCT placing four small circular ROIs in standardized regions of the cerebral dural venous system. The mean and maximum HU values were considered from each ROI, and the relative percentage variations were calculated (mean % variation and maximum % variation). We compared the highest measured value to the remaining three HU values through an ad-hoc formula based on the assumption that the thrombosed sinus has higher attenuation compared with the healthy sinuses. Percentage variations were employed to reflect how the attenuation of the thrombosed sinus deviates from the unaffected counterparts. The attenuation of the affected sinus was increased in patients with CVST, and consequently both the mean % and maximum % variations were increased. A mean % variation value of 12.97 and a maximum % variation value of 10.14 were found to be useful to distinguish patients with CVST from healthy subjects, with high sensitivity and specificity. Increased densitometric values were present in the site of venous thrombosis. A systematic, blind evaluation of the brain venous system can assist radiologists in identifying patients who need or do not need further imaging. |
| first_indexed | 2024-04-11T11:23:05Z |
| format | Article |
| id | doaj.art-c4afefca46c844e090af5ad092c3a15d |
| institution | Directory Open Access Journal |
| issn | 2379-1381 2379-139X |
| language | English |
| last_indexed | 2024-04-11T11:23:05Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tomography |
| spelling | doaj.art-c4afefca46c844e090af5ad092c3a15d2022-12-22T04:26:34ZengMDPI AGTomography2379-13812379-139X2021-12-01811910.3390/tomography8010001Cerebral Venous Thrombosis: A Challenging Diagnosis; A New Nonenhanced Computed Tomography Standardized Semi-Quantitative MethodAndrea Romano0Maria Camilla Rossi-Espagnet1Luca Pasquini2Alberto Di Napoli3Francesco Dellepiane4Giulia Butera5Giulia Moltoni6Olga Gagliardo7Alessandro Bozzao8Neuroradiology Unit, NESMOS Department, Sant’Andrea Hospital, La Sapienza University, 00189 Rome, ItalyNeuroradiology Unit, NESMOS Department, Sant’Andrea Hospital, La Sapienza University, 00189 Rome, ItalyNeuroradiology Unit, NESMOS Department, Sant’Andrea Hospital, La Sapienza University, 00189 Rome, ItalyNeuroradiology Unit, NESMOS Department, Sant’Andrea Hospital, La Sapienza University, 00189 Rome, ItalyNeuroradiology Unit, NESMOS Department, Sant’Andrea Hospital, La Sapienza University, 00189 Rome, ItalyNeuroradiology Unit, NESMOS Department, Sant’Andrea Hospital, La Sapienza University, 00189 Rome, ItalyNeuroradiology Unit, NESMOS Department, Sant’Andrea Hospital, La Sapienza University, 00189 Rome, ItalyNeuroradiology Unit, NESMOS Department, Sant’Andrea Hospital, La Sapienza University, 00189 Rome, ItalyNeuroradiology Unit, NESMOS Department, Sant’Andrea Hospital, La Sapienza University, 00189 Rome, ItalyCerebral venous sinus thrombosis (CVST) on non-contrast CT (NCCT) is often challenging to detect. We retrospectively selected 41 children and 36 adults with confirmed CVST and two age-matched control groups with comparable initial symptoms. We evaluated NCCT placing four small circular ROIs in standardized regions of the cerebral dural venous system. The mean and maximum HU values were considered from each ROI, and the relative percentage variations were calculated (mean % variation and maximum % variation). We compared the highest measured value to the remaining three HU values through an ad-hoc formula based on the assumption that the thrombosed sinus has higher attenuation compared with the healthy sinuses. Percentage variations were employed to reflect how the attenuation of the thrombosed sinus deviates from the unaffected counterparts. The attenuation of the affected sinus was increased in patients with CVST, and consequently both the mean % and maximum % variations were increased. A mean % variation value of 12.97 and a maximum % variation value of 10.14 were found to be useful to distinguish patients with CVST from healthy subjects, with high sensitivity and specificity. Increased densitometric values were present in the site of venous thrombosis. A systematic, blind evaluation of the brain venous system can assist radiologists in identifying patients who need or do not need further imaging.https://www.mdpi.com/2379-139X/8/1/1cerebral venous thrombosisdiagnosisstandardized methodCTROI based |
| spellingShingle | Andrea Romano Maria Camilla Rossi-Espagnet Luca Pasquini Alberto Di Napoli Francesco Dellepiane Giulia Butera Giulia Moltoni Olga Gagliardo Alessandro Bozzao Cerebral Venous Thrombosis: A Challenging Diagnosis; A New Nonenhanced Computed Tomography Standardized Semi-Quantitative Method Tomography cerebral venous thrombosis diagnosis standardized method CT ROI based |
| title | Cerebral Venous Thrombosis: A Challenging Diagnosis; A New Nonenhanced Computed Tomography Standardized Semi-Quantitative Method |
| title_full | Cerebral Venous Thrombosis: A Challenging Diagnosis; A New Nonenhanced Computed Tomography Standardized Semi-Quantitative Method |
| title_fullStr | Cerebral Venous Thrombosis: A Challenging Diagnosis; A New Nonenhanced Computed Tomography Standardized Semi-Quantitative Method |
| title_full_unstemmed | Cerebral Venous Thrombosis: A Challenging Diagnosis; A New Nonenhanced Computed Tomography Standardized Semi-Quantitative Method |
| title_short | Cerebral Venous Thrombosis: A Challenging Diagnosis; A New Nonenhanced Computed Tomography Standardized Semi-Quantitative Method |
| title_sort | cerebral venous thrombosis a challenging diagnosis a new nonenhanced computed tomography standardized semi quantitative method |
| topic | cerebral venous thrombosis diagnosis standardized method CT ROI based |
| url | https://www.mdpi.com/2379-139X/8/1/1 |
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