| Summary: | 【Abstract】 Objective: To establish an animal model
to replicate the blunt impact brain injury in forensic medicine.
Methods: Twenty-four New Zealand white rabbits were
randomly divided into control group (n=4), minor injury
group (n=10) and severe injury group (n=10). Based on the
BIM-Ⅱ Horizontal Bio-impact Machine, self-designed iron
bar was used to produce blunt brain injury. Two rabbits
from each injury group were randomly selected to monitor
the change of intracranial pressure (ICP) during the impact-ing process by pressure microsensors. Six hours after injury,
all the rabbits were dissected to observe the injury mor-phology and underwent routine pathological examination.
Results: Varying degrees of nervous system positive
signs were observed in all the injured rabbits. Within 6 hours,
the mortality rate was 1/10 in the minor injury group and 6/10
in the severe injury group. Morphological changes con-sisted of different levels of scalp hematoma, skull fracture,
epidural hematoma, subdural hematoma, subarachnoid hemo-rrhage and brain injury. At the moment of hitting, the ICP
was greater in severe injury group than in mild injury group;
and within the same group, the impact side showed positive
pressure while the opposite side showed negative pressure.
Conclusions: Under the rigidly-controlled experimen-tal condition, this animal model has a good reproducibility
and stable results. Meanwhile, it is able to simulate the mor-phology of iron strike-induced injury, thus can be used to
study the mechanism of blunt head injury in forensic
medicine.
Key words: Brain injuries; Forensic medicine;
Wounds, nonpenetrating; Models, animal; Rabbits
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