Copper in cancer: from limiting nutrient to therapeutic target
As an essential nutrient, copper’s redox properties are both beneficial and toxic to cells. Therefore, leveraging the characteristics of copper-dependent diseases or using copper toxicity to treat copper-sensitive diseases may offer new strategies for specific disease treatments. In particular, copp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1209156/full |
| _version_ | 1797796822134030336 |
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| author | Xiaolong Tang Xiaolong Tang Zaihua Yan Zaihua Yan Yandong Miao Wuhua Ha Zheng Li Lixia Yang Denghai Mi Denghai Mi |
| author_facet | Xiaolong Tang Xiaolong Tang Zaihua Yan Zaihua Yan Yandong Miao Wuhua Ha Zheng Li Lixia Yang Denghai Mi Denghai Mi |
| author_sort | Xiaolong Tang |
| collection | DOAJ |
| description | As an essential nutrient, copper’s redox properties are both beneficial and toxic to cells. Therefore, leveraging the characteristics of copper-dependent diseases or using copper toxicity to treat copper-sensitive diseases may offer new strategies for specific disease treatments. In particular, copper concentration is typically higher in cancer cells, making copper a critical limiting nutrient for cancer cell growth and proliferation. Hence, intervening in copper metabolism specific to cancer cells may become a potential tumor treatment strategy, directly impacting tumor growth and metastasis. In this review, we discuss the metabolism of copper in the body and summarize research progress on the role of copper in promoting tumor cell growth or inducing programmed cell death in tumor cells. Additionally, we elucidate the role of copper-related drugs in cancer treatment, intending to provide new perspectives for cancer treatment. |
| first_indexed | 2024-03-13T03:38:49Z |
| format | Article |
| id | doaj.art-c4b365a30cad4118bf0626614815ef5c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T03:38:49Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c4b365a30cad4118bf0626614815ef5c2023-06-23T13:31:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.12091561209156Copper in cancer: from limiting nutrient to therapeutic targetXiaolong Tang0Xiaolong Tang1Zaihua Yan2Zaihua Yan3Yandong Miao4Wuhua Ha5Zheng Li6Lixia Yang7Denghai Mi8Denghai Mi9The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe Second Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaThe Second Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaDepartment of Oncology, Yantai Affiliated Hospital of Binzhou Medical University, The Second Clinical Medical College of Binzhou Medical University, Yantai, Shandong, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaDivision of Thoracic Tumor Multimodality Treatment and Department of Radiation Oncology, Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaGansu Academy of Traditional Chinese Medicine, Lanzhou, Gansu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, ChinaGansu Academy of Traditional Chinese Medicine, Lanzhou, Gansu, ChinaAs an essential nutrient, copper’s redox properties are both beneficial and toxic to cells. Therefore, leveraging the characteristics of copper-dependent diseases or using copper toxicity to treat copper-sensitive diseases may offer new strategies for specific disease treatments. In particular, copper concentration is typically higher in cancer cells, making copper a critical limiting nutrient for cancer cell growth and proliferation. Hence, intervening in copper metabolism specific to cancer cells may become a potential tumor treatment strategy, directly impacting tumor growth and metastasis. In this review, we discuss the metabolism of copper in the body and summarize research progress on the role of copper in promoting tumor cell growth or inducing programmed cell death in tumor cells. Additionally, we elucidate the role of copper-related drugs in cancer treatment, intending to provide new perspectives for cancer treatment.https://www.frontiersin.org/articles/10.3389/fonc.2023.1209156/fullcopper metabolismanticancerCu chelatorsCu ionophorespotential drugs |
| spellingShingle | Xiaolong Tang Xiaolong Tang Zaihua Yan Zaihua Yan Yandong Miao Wuhua Ha Zheng Li Lixia Yang Denghai Mi Denghai Mi Copper in cancer: from limiting nutrient to therapeutic target Frontiers in Oncology copper metabolism anticancer Cu chelators Cu ionophores potential drugs |
| title | Copper in cancer: from limiting nutrient to therapeutic target |
| title_full | Copper in cancer: from limiting nutrient to therapeutic target |
| title_fullStr | Copper in cancer: from limiting nutrient to therapeutic target |
| title_full_unstemmed | Copper in cancer: from limiting nutrient to therapeutic target |
| title_short | Copper in cancer: from limiting nutrient to therapeutic target |
| title_sort | copper in cancer from limiting nutrient to therapeutic target |
| topic | copper metabolism anticancer Cu chelators Cu ionophores potential drugs |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1209156/full |
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