Exploring the Intervention Effects of Mulberry Polyphenols on Nonylphenol-Induced Neurobehavioral Toxicity Based on Thyroid Hormone and Deiodinase
The purpose of this study was to explore the intervention effects of mulberry polyphenols on neurobehavioral toxicity induced by nonylphenol (NP). 70 SPF male SD rats were randomly divided into seven groups: Blank control group (corn oil+saline), Mulberry control group [corn oil+mulberry crude extra...
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| Format: | Article |
| Language: | zho |
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The editorial department of Science and Technology of Food Industry
2022-09-01
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| Series: | Shipin gongye ke-ji |
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| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021120223 |
| _version_ | 1797983782114951168 |
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| author | Zhongyi LI Qianhua KE Huan LIU Wenna HAN Siyu ZHU Chunhong LIU |
| author_facet | Zhongyi LI Qianhua KE Huan LIU Wenna HAN Siyu ZHU Chunhong LIU |
| author_sort | Zhongyi LI |
| collection | DOAJ |
| description | The purpose of this study was to explore the intervention effects of mulberry polyphenols on neurobehavioral toxicity induced by nonylphenol (NP). 70 SPF male SD rats were randomly divided into seven groups: Blank control group (corn oil+saline), Mulberry control group [corn oil+mulberry crude extract (MCE)], NP exposure group (NP+saline), mulberry group (NP+MCE), anthocyanin group (NP+anthocyanin), resveratrol group (NP+resveratrol), combined group (NP+anthocyanin+resveratrol). The gavage amount of MCE was calculated according to 120 mg/kg·bw polyphenol content, and the anthocyanin and resveratrol content corresponded to the content in MCE. Open field test (OFT) and elevated plus maze (EPM) were used to evaluate the intervention effects of mulberry polyphenols on neurobehavioral toxicity of NP, and the levels of thyroxine (FT3, FT4), thyroid-stimulating hormone (TSH) and deiodinase (DIO1, DIO2, DIO3) were measured. The results showed that compared with NP group, all four intervention groups had varying degrees of intervention effects on the decrease of body weight growth rate, food utilization rate and organ coefficient of rats induced by NP (P<0.05 or P<0.01). The total distance of movement in OFT, the times of entering the central area, the total time of entering the open arm and staying time in EPM were significantly higher in the intervention groups than those in the NP group (P<0.05 or P<0.01), the levels of FT3, FT4 and TSH in serum increased significantly (P<0.05), while the content of deiodinase in liver decreased but had no significant difference. In summary: The MCE, anthocyanin and resveratrol could improve the neurobehavioral toxicity induced by NP, which might be related to the regulation of thyroid hormone, thyrotropin and deiodinase. |
| first_indexed | 2024-04-11T06:52:44Z |
| format | Article |
| id | doaj.art-c4b37e90aeb24750b3c19001f7ebfa5e |
| institution | Directory Open Access Journal |
| issn | 1002-0306 |
| language | zho |
| last_indexed | 2024-04-11T06:52:44Z |
| publishDate | 2022-09-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj.art-c4b37e90aeb24750b3c19001f7ebfa5e2022-12-22T04:39:08ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062022-09-01431839039810.13386/j.issn1002-0306.20211202232021120223-18Exploring the Intervention Effects of Mulberry Polyphenols on Nonylphenol-Induced Neurobehavioral Toxicity Based on Thyroid Hormone and DeiodinaseZhongyi LI0Qianhua KE1Huan LIU2Wenna HAN3Siyu ZHU4Chunhong LIU5College of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaThe purpose of this study was to explore the intervention effects of mulberry polyphenols on neurobehavioral toxicity induced by nonylphenol (NP). 70 SPF male SD rats were randomly divided into seven groups: Blank control group (corn oil+saline), Mulberry control group [corn oil+mulberry crude extract (MCE)], NP exposure group (NP+saline), mulberry group (NP+MCE), anthocyanin group (NP+anthocyanin), resveratrol group (NP+resveratrol), combined group (NP+anthocyanin+resveratrol). The gavage amount of MCE was calculated according to 120 mg/kg·bw polyphenol content, and the anthocyanin and resveratrol content corresponded to the content in MCE. Open field test (OFT) and elevated plus maze (EPM) were used to evaluate the intervention effects of mulberry polyphenols on neurobehavioral toxicity of NP, and the levels of thyroxine (FT3, FT4), thyroid-stimulating hormone (TSH) and deiodinase (DIO1, DIO2, DIO3) were measured. The results showed that compared with NP group, all four intervention groups had varying degrees of intervention effects on the decrease of body weight growth rate, food utilization rate and organ coefficient of rats induced by NP (P<0.05 or P<0.01). The total distance of movement in OFT, the times of entering the central area, the total time of entering the open arm and staying time in EPM were significantly higher in the intervention groups than those in the NP group (P<0.05 or P<0.01), the levels of FT3, FT4 and TSH in serum increased significantly (P<0.05), while the content of deiodinase in liver decreased but had no significant difference. In summary: The MCE, anthocyanin and resveratrol could improve the neurobehavioral toxicity induced by NP, which might be related to the regulation of thyroid hormone, thyrotropin and deiodinase.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021120223nonylphenolmulberry polyphenolthyroid hormoneopen field testelevated cross maze |
| spellingShingle | Zhongyi LI Qianhua KE Huan LIU Wenna HAN Siyu ZHU Chunhong LIU Exploring the Intervention Effects of Mulberry Polyphenols on Nonylphenol-Induced Neurobehavioral Toxicity Based on Thyroid Hormone and Deiodinase Shipin gongye ke-ji nonylphenol mulberry polyphenol thyroid hormone open field test elevated cross maze |
| title | Exploring the Intervention Effects of Mulberry Polyphenols on Nonylphenol-Induced Neurobehavioral Toxicity Based on Thyroid Hormone and Deiodinase |
| title_full | Exploring the Intervention Effects of Mulberry Polyphenols on Nonylphenol-Induced Neurobehavioral Toxicity Based on Thyroid Hormone and Deiodinase |
| title_fullStr | Exploring the Intervention Effects of Mulberry Polyphenols on Nonylphenol-Induced Neurobehavioral Toxicity Based on Thyroid Hormone and Deiodinase |
| title_full_unstemmed | Exploring the Intervention Effects of Mulberry Polyphenols on Nonylphenol-Induced Neurobehavioral Toxicity Based on Thyroid Hormone and Deiodinase |
| title_short | Exploring the Intervention Effects of Mulberry Polyphenols on Nonylphenol-Induced Neurobehavioral Toxicity Based on Thyroid Hormone and Deiodinase |
| title_sort | exploring the intervention effects of mulberry polyphenols on nonylphenol induced neurobehavioral toxicity based on thyroid hormone and deiodinase |
| topic | nonylphenol mulberry polyphenol thyroid hormone open field test elevated cross maze |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021120223 |
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