Properdin: A Novel Target for Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury

Properdin: A Novel Target for Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury

Background: Hypoxic-ischemic (HI) encephalopathy is a major cause of neonatal mortality and morbidity, with a global incidence of 3 per 1,000 live births. Intrauterine or perinatal complications, including maternal infection, constitute a major risk for the development of neonatal HI brain damage. D...

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Bibliographic Details
Main Authors: Claudia Sisa, Qudsiyah Agha-Shah, Balpreet Sanghera, Ariela Carno, Cordula Stover, Mariya Hristova
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
properdin
complement
alternative pathway
hypoxia
ischemia
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02610/full

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