Candidate Proficiency Test Chemicals to Address Industrial Chemical Applicability Domains for in vitro Human Cytochrome P450 Enzyme Induction

Candidate Proficiency Test Chemicals to Address Industrial Chemical Applicability Domains for in vitro Human Cytochrome P450 Enzyme Induction

Cytochrome P450 (CYP) enzymes play a key role in the metabolism of both xenobiotics and endogenous chemicals, and the activity of some CYP isoforms are susceptible to induction and/or inhibition by certain chemicals. As CYP induction/inhibition can bring about significant alterations in the level of...

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Bibliographic Details
Main Authors: Miriam Naomi Jacobs, Barbara Kubickova, Eugene Boshoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Toxicology
Subjects:
CYP
P450
validation
test guideline
HepaRG
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.880818/full

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