Single-cell RNA-sequencing of cellular heterogeneity and pathogenic mechanisms in paraquat-induced Parkinson's disease with depression

Single-cell RNA-sequencing of cellular heterogeneity and pathogenic mechanisms in paraquat-induced Parkinson's disease with depression

Parkinson's disease (PD) is among the most prevalent neurodegenerative diseases, and approximately one third of patients with PD are estimated to have depression. Paraquat (PQ) exposure is an important environmental risk factor for PD. In this study, we established a mouse model of PQ-induced P...

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Detalhes bibliográficos
Principais autores: Yali Weng, Yu Zhang, Yinhan Li, Xinpei Lin, Zhenkun Guo, Hong Hu, Wenya Shao, Guangxia Yu, Fuli Zheng, Ping Cai, Huangyuan Li, Siying Wu
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2024-03-01
coleção:Ecotoxicology and Environmental Safety
Assuntos:
Parkinson's disease
Depression
Single-cell RNA sequencing
Cellular heterogeneity
Glutamatergic cluster
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0147651324002446

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