Mortality in Eosinophilic Esophagitis – a nationwide, population-based matched cohort study from 2005 to 2017
Background: There is a lack of knowledge about mortality in eosinophilic esophagitis (EoE). Therefore, this study aimed to examine the mortality in EoE. Methods: A nationwide, population-based matched cohort study was conducted of all EoE patients in Sweden diagnosed between July 2005 and December 2...
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| Format: | Article |
| Language: | English |
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Upsala Medical Society
2021-08-01
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| Series: | Upsala Journal of Medical Sciences |
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| Online Access: | https://ujms.net/index.php/ujms/article/view/7688/13798 |
| _version_ | 1797707015009599488 |
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| author | Lovisa Röjler John J. Garber Bjorn Roelstraete Marjorie M. Walker Jonas F. Ludvigsson |
| author_facet | Lovisa Röjler John J. Garber Bjorn Roelstraete Marjorie M. Walker Jonas F. Ludvigsson |
| author_sort | Lovisa Röjler |
| collection | DOAJ |
| description | Background: There is a lack of knowledge about mortality in eosinophilic esophagitis (EoE). Therefore, this study aimed to examine the mortality in EoE. Methods: A nationwide, population-based matched cohort study was conducted of all EoE patients in Sweden diagnosed between July 2005 and December 2017. Individuals with EoE (n = 1,625) were identified through prospectively recorded histopathology codes from all gastrointestinal pathology reports in Sweden, representing 28 pathology departments (the ESPRESSO study). Each individual with EoE was then matched with up to five reference individuals from the general population (n = 8,003) for age, sex, year of birth, and place of residence. We used the Cox proportional hazard modeling to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (95% CI) while adjusting for other potential confounders. In sensitivity analyses, mortality in EoE patients was compared with mortality in their siblings. Results: Through December 2017, 34 deaths were confirmed in EoE patients (4.60 per 1,000 person-years) compared with 165 in reference individuals (4.57 per 1,000 person-years). This rate corresponds to an aHR of 0.97 (95% CI = 0.67–1.40). HRs were similar in males (aHR = 1.00 [0.66–1.51]) and females (aHR = 0.92 [0.38–2.18]). We observed no increased risk in mortality due to esophageal or other gastrointestinal cancers in patients with EoE (aHR = 1.02 [0.51–2.02]).Mortality was similar in EoE patients and their siblings (aHR = 0.91 [0.44–1.85]). Conclusion: In this nationwide, population-based matched cohort study in Sweden, there was no increased risk of death in patients with EoE compared with their siblings and the general population. |
| first_indexed | 2024-03-12T06:01:05Z |
| format | Article |
| id | doaj.art-c4b87927b7094287905fcff848a1b7ee |
| institution | Directory Open Access Journal |
| issn | 0300-9734 2000-1967 |
| language | English |
| last_indexed | 2024-03-12T06:01:05Z |
| publishDate | 2021-08-01 |
| publisher | Upsala Medical Society |
| record_format | Article |
| series | Upsala Journal of Medical Sciences |
| spelling | doaj.art-c4b87927b7094287905fcff848a1b7ee2023-09-03T04:11:06ZengUpsala Medical SocietyUpsala Journal of Medical Sciences0300-97342000-19672021-08-011261910.48101/ujms.v126.76887688Mortality in Eosinophilic Esophagitis – a nationwide, population-based matched cohort study from 2005 to 2017Lovisa Röjler0John J. Garber1Bjorn Roelstraete2Marjorie M. Walker3Jonas F. Ludvigsson4Department of Pediatrics, Örebro University Hospital, SwedenGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, USADepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenDepartment Anatomical Pathology University of Newcastle Faculty of Health and Medicine School of Medicine and Public Health Callaghan, NSW, AustraliaDepartment of Pediatrics, Örebro University Hospital, SwedenBackground: There is a lack of knowledge about mortality in eosinophilic esophagitis (EoE). Therefore, this study aimed to examine the mortality in EoE. Methods: A nationwide, population-based matched cohort study was conducted of all EoE patients in Sweden diagnosed between July 2005 and December 2017. Individuals with EoE (n = 1,625) were identified through prospectively recorded histopathology codes from all gastrointestinal pathology reports in Sweden, representing 28 pathology departments (the ESPRESSO study). Each individual with EoE was then matched with up to five reference individuals from the general population (n = 8,003) for age, sex, year of birth, and place of residence. We used the Cox proportional hazard modeling to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (95% CI) while adjusting for other potential confounders. In sensitivity analyses, mortality in EoE patients was compared with mortality in their siblings. Results: Through December 2017, 34 deaths were confirmed in EoE patients (4.60 per 1,000 person-years) compared with 165 in reference individuals (4.57 per 1,000 person-years). This rate corresponds to an aHR of 0.97 (95% CI = 0.67–1.40). HRs were similar in males (aHR = 1.00 [0.66–1.51]) and females (aHR = 0.92 [0.38–2.18]). We observed no increased risk in mortality due to esophageal or other gastrointestinal cancers in patients with EoE (aHR = 1.02 [0.51–2.02]).Mortality was similar in EoE patients and their siblings (aHR = 0.91 [0.44–1.85]). Conclusion: In this nationwide, population-based matched cohort study in Sweden, there was no increased risk of death in patients with EoE compared with their siblings and the general population.https://ujms.net/index.php/ujms/article/view/7688/13798deathcancereosinophilic esophagitismortalitypopulation-based |
| spellingShingle | Lovisa Röjler John J. Garber Bjorn Roelstraete Marjorie M. Walker Jonas F. Ludvigsson Mortality in Eosinophilic Esophagitis – a nationwide, population-based matched cohort study from 2005 to 2017 Upsala Journal of Medical Sciences death cancer eosinophilic esophagitis mortality population-based |
| title | Mortality in Eosinophilic Esophagitis – a nationwide, population-based matched cohort study from 2005 to 2017 |
| title_full | Mortality in Eosinophilic Esophagitis – a nationwide, population-based matched cohort study from 2005 to 2017 |
| title_fullStr | Mortality in Eosinophilic Esophagitis – a nationwide, population-based matched cohort study from 2005 to 2017 |
| title_full_unstemmed | Mortality in Eosinophilic Esophagitis – a nationwide, population-based matched cohort study from 2005 to 2017 |
| title_short | Mortality in Eosinophilic Esophagitis – a nationwide, population-based matched cohort study from 2005 to 2017 |
| title_sort | mortality in eosinophilic esophagitis a nationwide population based matched cohort study from 2005 to 2017 |
| topic | death cancer eosinophilic esophagitis mortality population-based |
| url | https://ujms.net/index.php/ujms/article/view/7688/13798 |
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