HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver, and currently the second most common cause of cancer-related deaths worldwide with increasing incidence and poor prognosis. Exosomes are now considered as important mediators of host anti-tumor immune response as well as tumor cell...
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| Format: | Article |
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MDPI AG
2019-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/6/558 |
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| author | Qiuju Han Huajun Zhao Yu Jiang Chunlai Yin Jian Zhang |
| author_facet | Qiuju Han Huajun Zhao Yu Jiang Chunlai Yin Jian Zhang |
| author_sort | Qiuju Han |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a primary malignancy of the liver, and currently the second most common cause of cancer-related deaths worldwide with increasing incidence and poor prognosis. Exosomes are now considered as important mediators of host anti-tumor immune response as well as tumor cell immune escape. HCC-derived exosomes have been shown to attenuate the cytotoxicity of T-cells and NK cells, and promote the immuno-suppressive M2 macrophages, N2 neutrophils, and Bregs. These exosomes harbor several immune-related non-coding RNAs and proteins that drive immune-escape and tumor progression, and thus may serve as potential diagnostic biomarkers and therapeutic targets for HCC. In a previous study, we identified miR146a as an exosomal factor that promotes M2-polarization and suppresses the anti-HCC function of T-cells. In this review, we summarized the role of tumor-derived exosomes and their key components in mediating tumor immune escape during HCC development. |
| first_indexed | 2024-03-12T20:10:58Z |
| format | Article |
| id | doaj.art-c4b8d8096ec34f7b907581d36a8a1a65 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T20:10:58Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c4b8d8096ec34f7b907581d36a8a1a652023-08-02T01:45:35ZengMDPI AGCells2073-44092019-06-018655810.3390/cells8060558cells8060558HCC-Derived Exosomes: Critical Player and Target for Cancer Immune EscapeQiuju Han0Huajun Zhao1Yu Jiang2Chunlai Yin3Jian Zhang4Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua West Road, Jinan 250012, ChinaInstitute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua West Road, Jinan 250012, ChinaInstitute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua West Road, Jinan 250012, ChinaInstitute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua West Road, Jinan 250012, ChinaInstitute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua West Road, Jinan 250012, ChinaHepatocellular carcinoma (HCC) is a primary malignancy of the liver, and currently the second most common cause of cancer-related deaths worldwide with increasing incidence and poor prognosis. Exosomes are now considered as important mediators of host anti-tumor immune response as well as tumor cell immune escape. HCC-derived exosomes have been shown to attenuate the cytotoxicity of T-cells and NK cells, and promote the immuno-suppressive M2 macrophages, N2 neutrophils, and Bregs. These exosomes harbor several immune-related non-coding RNAs and proteins that drive immune-escape and tumor progression, and thus may serve as potential diagnostic biomarkers and therapeutic targets for HCC. In a previous study, we identified miR146a as an exosomal factor that promotes M2-polarization and suppresses the anti-HCC function of T-cells. In this review, we summarized the role of tumor-derived exosomes and their key components in mediating tumor immune escape during HCC development.https://www.mdpi.com/2073-4409/8/6/558HCCexosomeimmune escapemiRNA |
| spellingShingle | Qiuju Han Huajun Zhao Yu Jiang Chunlai Yin Jian Zhang HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape Cells HCC exosome immune escape miRNA |
| title | HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape |
| title_full | HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape |
| title_fullStr | HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape |
| title_full_unstemmed | HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape |
| title_short | HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape |
| title_sort | hcc derived exosomes critical player and target for cancer immune escape |
| topic | HCC exosome immune escape miRNA |
| url | https://www.mdpi.com/2073-4409/8/6/558 |
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