Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation

Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation

Objectives: To determine the role of MYL4 regulation of lysosomal function and its disturbance in fibrotic atrial cardiomyopathy. Background: We have previously demonstrated that the atrial-specific essential light chain protein MYL4 is required for atrial contractile, electrical, and structural int...

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Bibliographic Details
Main Authors: Yuan Zhong, Kai Tang, Stanley Nattel, Ming Zhai, Shiyu Gong, Qing Yu, Yanxi Zeng, Guangxi E, Nuerbiyemu Maimaitiaili, Jun Wang, Yawei Xu, Wenhui Peng, Hailing Li
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Redox Biology
Subjects:
Myosin light chain 4
Atrial cardiomyopathy
Autophagy
Lysosome
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000071

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http://www.sciencedirect.com/science/article/pii/S2213231723000071

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