Activation of the canonical Wnt/β-catenin pathway in ATF3-induced mammary tumors.

Activation of the canonical Wnt/β-catenin pathway in ATF3-induced mammary tumors.

Female transgenic mice that constitutively overexpress the transcription factor ATF3 in the basal epithelium of the mammary gland develop mammary carcinomas with high frequency, but only if allowed to mate and raise pups early in life. This transgenic mouse model system reproduces some features of h...

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Bibliographic Details
Main Authors: Leqin Yan, Luis Della Coletta, K Leslie Powell, Jianjun Shen, Howard Thames, C Marcelo Aldaz, Michael C MacLeod
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3031586?pdf=render

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