Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors
In this study, new pyridine-based imine compounds (8-10) were synthesized and docking studies of these compounds against D2 Dopamine receptor (6CM4) were performed. The structures of these compounds, which were synthesized using the microwave method, were determined by 1H-NMR, 13C-NMR and elemental...
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| Format: | Article |
| Language: | English |
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Hitit University
2023-06-01
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| Series: | Hittite Journal of Science and Engineering |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2959556 |
| _version_ | 1797662672291889152 |
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| author | Sertan Aytaç |
| author_facet | Sertan Aytaç |
| author_sort | Sertan Aytaç |
| collection | DOAJ |
| description | In this study, new pyridine-based imine compounds (8-10) were synthesized and docking studies of these compounds against D2 Dopamine receptor (6CM4) were performed. The structures of these compounds, which were synthesized using the microwave method, were determined by 1H-NMR, 13C-NMR and elemental analysis techniques. The binding energy values vary range from -6.79 to -7.07 kcal/mol with D2 Dopamine Receptor/PDB: 6MC4. Compound 10 (-7.07 kcal mol-1) showed better binding energy than 9 (-6.95 kcal mol-1) and 8 (-6.79 kcal/mol). |
| first_indexed | 2024-03-11T19:03:43Z |
| format | Article |
| id | doaj.art-c4c3b678c8f147068818a6826f9e4b71 |
| institution | Directory Open Access Journal |
| issn | 2148-4171 |
| language | English |
| last_indexed | 2024-03-11T19:03:43Z |
| publishDate | 2023-06-01 |
| publisher | Hitit University |
| record_format | Article |
| series | Hittite Journal of Science and Engineering |
| spelling | doaj.art-c4c3b678c8f147068818a6826f9e4b712023-10-10T11:17:29ZengHitit UniversityHittite Journal of Science and Engineering2148-41712023-06-0110216116510.17350/HJSE19030000303150Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 ReceptorsSertan Aytaç0Kırşehir Ahi Evran ÜniversitesiIn this study, new pyridine-based imine compounds (8-10) were synthesized and docking studies of these compounds against D2 Dopamine receptor (6CM4) were performed. The structures of these compounds, which were synthesized using the microwave method, were determined by 1H-NMR, 13C-NMR and elemental analysis techniques. The binding energy values vary range from -6.79 to -7.07 kcal/mol with D2 Dopamine Receptor/PDB: 6MC4. Compound 10 (-7.07 kcal mol-1) showed better binding energy than 9 (-6.95 kcal mol-1) and 8 (-6.79 kcal/mol).https://dergipark.org.tr/tr/download/article-file/2959556β-phenylethylaminedopamineimined2 receptormolecular dockingβ-phenylethylaminedopamineimined2 receptormolecular docking |
| spellingShingle | Sertan Aytaç Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors Hittite Journal of Science and Engineering β-phenylethylamine dopamine imine d2 receptor molecular docking β-phenylethylamine dopamine imine d2 receptor molecular docking |
| title | Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors |
| title_full | Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors |
| title_fullStr | Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors |
| title_full_unstemmed | Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors |
| title_short | Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors |
| title_sort | synthesis of pyridine based imine compounds and molecular docking studies against dopamine d2 receptors |
| topic | β-phenylethylamine dopamine imine d2 receptor molecular docking β-phenylethylamine dopamine imine d2 receptor molecular docking |
| url | https://dergipark.org.tr/tr/download/article-file/2959556 |
| work_keys_str_mv | AT sertanaytac synthesisofpyridinebasediminecompoundsandmoleculardockingstudiesagainstdopamined2receptors |