The prognosis of different distant metastases pattern in malignant tumors of the adrenal glands: A population-based retrospective study.
<h4>Introduction</h4>The present existing data on the association of metastatic sites and prognosis of patients with metastatic adrenal malignancy are limited. This study aims to investigate the impact of different distant metastases pattern on the survival of patients with adrenal malig...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0264431 |
| _version_ | 1798022738161434624 |
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| author | Jia Miao Haibin Wei Jianxin Cui Qi Zhang Feng Liu Zujie Mao Dahong Zhang |
| author_facet | Jia Miao Haibin Wei Jianxin Cui Qi Zhang Feng Liu Zujie Mao Dahong Zhang |
| author_sort | Jia Miao |
| collection | DOAJ |
| description | <h4>Introduction</h4>The present existing data on the association of metastatic sites and prognosis of patients with metastatic adrenal malignancy are limited. This study aims to investigate the impact of different distant metastases pattern on the survival of patients with adrenal malignancy.<h4>Methods</h4>A dataset from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) 18 Registries (2000-2017) was selected for a retrospective metastatic adrenal malignancy cohort study. There was information on distribution of metastatic lesions in bone, brain, liver, and lung in the SEER database. Kaplan-Meier analysis and nomogram analyses were applied to compare the survival distribution of cases. Univariate and multivariate cox regression models were used to analyze survival outcomes.<h4>Results</h4>From the SEER database, a total of 980 patients with primary metastatic adrenal malignancy from 2010 to 2017 were enrolled in this cohort study. Based on the initial metastatic sites, 42.3%, 38.4%, 30.5%, and 4.9% of patients were found bone, liver, lung, and brain metastasis, respectively. Patients who had a single site of distant metastases accounted for 52.6% (515/980) and had a better overall survival (OS) and cancer-specific survival (CSS) (both P < 0.001). In contrast with the tumor arising from the cortex, the tumor from the medulla showed better survival outcomes in both OS and CSS (P < 0.001).<h4>Conclusion</h4>Different histological types possess various metastatic features and prognostic values. Understanding these differences may contribute to designing targeted pre-treatment assessment of primary metastatic adrenal malignancy and creating a personalized curative intervention. |
| first_indexed | 2024-04-11T17:34:54Z |
| format | Article |
| id | doaj.art-c4c4cf0250854f91aab54d85011b6f6d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T17:34:54Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c4c4cf0250854f91aab54d85011b6f6d2022-12-22T04:11:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01173e026443110.1371/journal.pone.0264431The prognosis of different distant metastases pattern in malignant tumors of the adrenal glands: A population-based retrospective study.Jia MiaoHaibin WeiJianxin CuiQi ZhangFeng LiuZujie MaoDahong Zhang<h4>Introduction</h4>The present existing data on the association of metastatic sites and prognosis of patients with metastatic adrenal malignancy are limited. This study aims to investigate the impact of different distant metastases pattern on the survival of patients with adrenal malignancy.<h4>Methods</h4>A dataset from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) 18 Registries (2000-2017) was selected for a retrospective metastatic adrenal malignancy cohort study. There was information on distribution of metastatic lesions in bone, brain, liver, and lung in the SEER database. Kaplan-Meier analysis and nomogram analyses were applied to compare the survival distribution of cases. Univariate and multivariate cox regression models were used to analyze survival outcomes.<h4>Results</h4>From the SEER database, a total of 980 patients with primary metastatic adrenal malignancy from 2010 to 2017 were enrolled in this cohort study. Based on the initial metastatic sites, 42.3%, 38.4%, 30.5%, and 4.9% of patients were found bone, liver, lung, and brain metastasis, respectively. Patients who had a single site of distant metastases accounted for 52.6% (515/980) and had a better overall survival (OS) and cancer-specific survival (CSS) (both P < 0.001). In contrast with the tumor arising from the cortex, the tumor from the medulla showed better survival outcomes in both OS and CSS (P < 0.001).<h4>Conclusion</h4>Different histological types possess various metastatic features and prognostic values. Understanding these differences may contribute to designing targeted pre-treatment assessment of primary metastatic adrenal malignancy and creating a personalized curative intervention.https://doi.org/10.1371/journal.pone.0264431 |
| spellingShingle | Jia Miao Haibin Wei Jianxin Cui Qi Zhang Feng Liu Zujie Mao Dahong Zhang The prognosis of different distant metastases pattern in malignant tumors of the adrenal glands: A population-based retrospective study. PLoS ONE |
| title | The prognosis of different distant metastases pattern in malignant tumors of the adrenal glands: A population-based retrospective study. |
| title_full | The prognosis of different distant metastases pattern in malignant tumors of the adrenal glands: A population-based retrospective study. |
| title_fullStr | The prognosis of different distant metastases pattern in malignant tumors of the adrenal glands: A population-based retrospective study. |
| title_full_unstemmed | The prognosis of different distant metastases pattern in malignant tumors of the adrenal glands: A population-based retrospective study. |
| title_short | The prognosis of different distant metastases pattern in malignant tumors of the adrenal glands: A population-based retrospective study. |
| title_sort | prognosis of different distant metastases pattern in malignant tumors of the adrenal glands a population based retrospective study |
| url | https://doi.org/10.1371/journal.pone.0264431 |
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