Evaluation of the Diagnostic Capability of Spectralis SD-OCT 8 × 8 Posterior Pole Software with the Grid Tilted at 7 Degrees and Horizontalized in Glaucoma
<b>Background</b>: The goal was to evaluate the diagnostic capability of different parameters obtained with the posterior pole (PP) software in Spectralis SD-OCT with the 8 × 8 grid tilted at 7° and horizontalized in glaucomatous eyes. <b>Methods</b>: A total of 299 eyes were...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/13/4/1016 |
| _version_ | 1797297895338147840 |
|---|---|
| author | Aurora Alvarez-Sarrion Jose Javier Garcia-Medina Ana Palazon-Cabanes Maria Dolores Pinazo-Duran Monica Del-Rio-Vellosillo |
| author_facet | Aurora Alvarez-Sarrion Jose Javier Garcia-Medina Ana Palazon-Cabanes Maria Dolores Pinazo-Duran Monica Del-Rio-Vellosillo |
| author_sort | Aurora Alvarez-Sarrion |
| collection | DOAJ |
| description | <b>Background</b>: The goal was to evaluate the diagnostic capability of different parameters obtained with the posterior pole (PP) software in Spectralis SD-OCT with the 8 × 8 grid tilted at 7° and horizontalized in glaucomatous eyes. <b>Methods</b>: A total of 299 eyes were included, comprising 136 healthy eyes and 163 with primary open-angle glaucoma (POAG). The following segmentations were evaluated: complete retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), GCL and inner plexiform layer (GCLIPL), ganglion cell complex (GCC), outer plexiform layer and outer nuclear layer (OPLONL), inner retinal layer (IRL), and outer retinal layer (ORL). Different patterns of macular damage were represented using heatmaps for each studied layer, where the areas under the curve (AUROC) values and a retinal thickness cutoff point were defined to discriminate POAG patients. Results: There was not any difference in the diagnostic capability for detecting glaucoma between the grid tilted at 7° and horizontalized. The macular segmentations that offer the highest diagnostic ability in glaucoma discrimination were, in the following order, RNFL (AUROC = 0.796), GCC (AUROC = 0.785), GCL (AUROC = 0.784), GCLIPL (AUROC = 0.770), IRL (AUROC = 0.755), and the complete retina (AUROC = 0.752). In contrast, ORL and OPLONL do not appear to be helpful for discriminating POAG. <b>Conclusions</b>: Some results of PP software may be useful for discriminating POAG. |
| first_indexed | 2024-03-07T22:27:00Z |
| format | Article |
| id | doaj.art-c4c51b3285ec440fba6183bcf2a81c8d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-07T22:27:00Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c4c51b3285ec440fba6183bcf2a81c8d2024-02-23T15:22:02ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01134101610.3390/jcm13041016Evaluation of the Diagnostic Capability of Spectralis SD-OCT 8 × 8 Posterior Pole Software with the Grid Tilted at 7 Degrees and Horizontalized in GlaucomaAurora Alvarez-Sarrion0Jose Javier Garcia-Medina1Ana Palazon-Cabanes2Maria Dolores Pinazo-Duran3Monica Del-Rio-Vellosillo4Department of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, SpainDepartment of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, SpainDepartment of Ophthalmology, Hospital Virgen del Castillo, Yecla, 30510 Murcia, SpainOphthalmic Research Unit “Santiago Grisolia”, 28029 Valencia, SpainDepartment of Anesthesiology, General University Hospital Morales Meseguer, 30008 Murcia, Spain<b>Background</b>: The goal was to evaluate the diagnostic capability of different parameters obtained with the posterior pole (PP) software in Spectralis SD-OCT with the 8 × 8 grid tilted at 7° and horizontalized in glaucomatous eyes. <b>Methods</b>: A total of 299 eyes were included, comprising 136 healthy eyes and 163 with primary open-angle glaucoma (POAG). The following segmentations were evaluated: complete retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), GCL and inner plexiform layer (GCLIPL), ganglion cell complex (GCC), outer plexiform layer and outer nuclear layer (OPLONL), inner retinal layer (IRL), and outer retinal layer (ORL). Different patterns of macular damage were represented using heatmaps for each studied layer, where the areas under the curve (AUROC) values and a retinal thickness cutoff point were defined to discriminate POAG patients. Results: There was not any difference in the diagnostic capability for detecting glaucoma between the grid tilted at 7° and horizontalized. The macular segmentations that offer the highest diagnostic ability in glaucoma discrimination were, in the following order, RNFL (AUROC = 0.796), GCC (AUROC = 0.785), GCL (AUROC = 0.784), GCLIPL (AUROC = 0.770), IRL (AUROC = 0.755), and the complete retina (AUROC = 0.752). In contrast, ORL and OPLONL do not appear to be helpful for discriminating POAG. <b>Conclusions</b>: Some results of PP software may be useful for discriminating POAG.https://www.mdpi.com/2077-0383/13/4/1016glaucomaposterior polemaculathicknesslayersegmentation |
| spellingShingle | Aurora Alvarez-Sarrion Jose Javier Garcia-Medina Ana Palazon-Cabanes Maria Dolores Pinazo-Duran Monica Del-Rio-Vellosillo Evaluation of the Diagnostic Capability of Spectralis SD-OCT 8 × 8 Posterior Pole Software with the Grid Tilted at 7 Degrees and Horizontalized in Glaucoma Journal of Clinical Medicine glaucoma posterior pole macula thickness layer segmentation |
| title | Evaluation of the Diagnostic Capability of Spectralis SD-OCT 8 × 8 Posterior Pole Software with the Grid Tilted at 7 Degrees and Horizontalized in Glaucoma |
| title_full | Evaluation of the Diagnostic Capability of Spectralis SD-OCT 8 × 8 Posterior Pole Software with the Grid Tilted at 7 Degrees and Horizontalized in Glaucoma |
| title_fullStr | Evaluation of the Diagnostic Capability of Spectralis SD-OCT 8 × 8 Posterior Pole Software with the Grid Tilted at 7 Degrees and Horizontalized in Glaucoma |
| title_full_unstemmed | Evaluation of the Diagnostic Capability of Spectralis SD-OCT 8 × 8 Posterior Pole Software with the Grid Tilted at 7 Degrees and Horizontalized in Glaucoma |
| title_short | Evaluation of the Diagnostic Capability of Spectralis SD-OCT 8 × 8 Posterior Pole Software with the Grid Tilted at 7 Degrees and Horizontalized in Glaucoma |
| title_sort | evaluation of the diagnostic capability of spectralis sd oct 8 8 posterior pole software with the grid tilted at 7 degrees and horizontalized in glaucoma |
| topic | glaucoma posterior pole macula thickness layer segmentation |
| url | https://www.mdpi.com/2077-0383/13/4/1016 |
| work_keys_str_mv | AT auroraalvarezsarrion evaluationofthediagnosticcapabilityofspectralissdoct88posteriorpolesoftwarewiththegridtiltedat7degreesandhorizontalizedinglaucoma AT josejaviergarciamedina evaluationofthediagnosticcapabilityofspectralissdoct88posteriorpolesoftwarewiththegridtiltedat7degreesandhorizontalizedinglaucoma AT anapalazoncabanes evaluationofthediagnosticcapabilityofspectralissdoct88posteriorpolesoftwarewiththegridtiltedat7degreesandhorizontalizedinglaucoma AT mariadolorespinazoduran evaluationofthediagnosticcapabilityofspectralissdoct88posteriorpolesoftwarewiththegridtiltedat7degreesandhorizontalizedinglaucoma AT monicadelriovellosillo evaluationofthediagnosticcapabilityofspectralissdoct88posteriorpolesoftwarewiththegridtiltedat7degreesandhorizontalizedinglaucoma |