Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from <i>Polygoni cuspidati</i> Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin?
The low bioavailability of resveratrol and polydatin obtained from <i>Polygoni cuspidati</i> extract limits the application of their pro-health properties. While nanofibers have attracted increasing attention in nutrition delivery due to their special properties, including an increase in...
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MDPI AG
2022-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/19/3897 |
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| author | Magdalena Paczkowska-Walendowska Andrzej Miklaszewski Judyta Cielecka-Piontek |
| author_facet | Magdalena Paczkowska-Walendowska Andrzej Miklaszewski Judyta Cielecka-Piontek |
| author_sort | Magdalena Paczkowska-Walendowska |
| collection | DOAJ |
| description | The low bioavailability of resveratrol and polydatin obtained from <i>Polygoni cuspidati</i> extract limits the application of their pro-health properties. While nanofibers have attracted increasing attention in nutrition delivery due to their special properties, including an increase in the dissolution and permeability, which affects the bioavailability. Therefore, it is justified to obtain nanofibers from <i>Polygoni cuspidati</i> extract, which showed antioxidant and anti-inflammatory properties as a result of a presence of stilbene analogs in the <i>Polygoni cuspidati</i> extract (especially resveratrol and polydatin). In the first stage of the work, using the Design of Experiment (DoE) approach, the <i>Polygoni cuspidati</i> extract (70% of methanol, temperature 70 °C and 4 cycles) was obtained, which showed the best antioxidant and anti-inflammatory properties. Using the <i>Polygoni cuspidati</i> extract as a substrate, nanofibers were obtained by electrospinning. The identification of nanofibers was confirmed on the basis of the analysis of changes in XRPD diffractograms, SEM picture and FTIR-ATR spectra. Obtaining nanofibers from the <i>Polygoni cuspidati</i> extract significantly improved the solubility of resveratrol and polydatin (approx. 6-fold comparing to pure substance). As a consequence, the penetration coefficients of both tested resveratrol and polydatin also increased. The proposed strategy for the preparation of nanofibers from the <i>Polygoni cuspidati</i> extract is an innovative approach to better use the synergy of biological action of active compounds present in extracts. It is especially during the development of nutraceuticals based on the use of selected stilbenes. |
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| format | Article |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T21:21:10Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c4c63d3c03d94bbd9e1f584ef1c867442023-11-23T21:22:08ZengMDPI AGNutrients2072-66432022-09-011419389710.3390/nu14193897Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from <i>Polygoni cuspidati</i> Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin?Magdalena Paczkowska-Walendowska0Andrzej Miklaszewski1Judyta Cielecka-Piontek2Department of Pharmacognosy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandInstitute of Materials Science and Engineering, Faculty of Materials Engineering and Technical Physics, Poznan University of Technology, Jana Pawła II 24, 61-138 Poznan, PolandDepartment of Pharmacognosy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandThe low bioavailability of resveratrol and polydatin obtained from <i>Polygoni cuspidati</i> extract limits the application of their pro-health properties. While nanofibers have attracted increasing attention in nutrition delivery due to their special properties, including an increase in the dissolution and permeability, which affects the bioavailability. Therefore, it is justified to obtain nanofibers from <i>Polygoni cuspidati</i> extract, which showed antioxidant and anti-inflammatory properties as a result of a presence of stilbene analogs in the <i>Polygoni cuspidati</i> extract (especially resveratrol and polydatin). In the first stage of the work, using the Design of Experiment (DoE) approach, the <i>Polygoni cuspidati</i> extract (70% of methanol, temperature 70 °C and 4 cycles) was obtained, which showed the best antioxidant and anti-inflammatory properties. Using the <i>Polygoni cuspidati</i> extract as a substrate, nanofibers were obtained by electrospinning. The identification of nanofibers was confirmed on the basis of the analysis of changes in XRPD diffractograms, SEM picture and FTIR-ATR spectra. Obtaining nanofibers from the <i>Polygoni cuspidati</i> extract significantly improved the solubility of resveratrol and polydatin (approx. 6-fold comparing to pure substance). As a consequence, the penetration coefficients of both tested resveratrol and polydatin also increased. The proposed strategy for the preparation of nanofibers from the <i>Polygoni cuspidati</i> extract is an innovative approach to better use the synergy of biological action of active compounds present in extracts. It is especially during the development of nutraceuticals based on the use of selected stilbenes.https://www.mdpi.com/2072-6643/14/19/3897<i>Polygoni cuspidate</i> extractnanofibersresveratrolpolydatinbioavailability |
| spellingShingle | Magdalena Paczkowska-Walendowska Andrzej Miklaszewski Judyta Cielecka-Piontek Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from <i>Polygoni cuspidati</i> Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin? Nutrients <i>Polygoni cuspidate</i> extract nanofibers resveratrol polydatin bioavailability |
| title | Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from <i>Polygoni cuspidati</i> Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin? |
| title_full | Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from <i>Polygoni cuspidati</i> Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin? |
| title_fullStr | Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from <i>Polygoni cuspidati</i> Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin? |
| title_full_unstemmed | Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from <i>Polygoni cuspidati</i> Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin? |
| title_short | Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from <i>Polygoni cuspidati</i> Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin? |
| title_sort | is it possible to improve the bioavailability of resveratrol and polydatin derived from i polygoni cuspidati i radix as a result of preparing electrospun nanofibers based on polyvinylpyrrolidone cyclodextrin |
| topic | <i>Polygoni cuspidate</i> extract nanofibers resveratrol polydatin bioavailability |
| url | https://www.mdpi.com/2072-6643/14/19/3897 |
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