Association of Rare Recurrent Copy Number Variants With Congenital Heart Defects Based on Next-Generation Sequencing Data From Family Trios

Association of Rare Recurrent Copy Number Variants With Congenital Heart Defects Based on Next-Generation Sequencing Data From Family Trios

Congenital heart defects (CHDs) are a common birth defect, affecting approximately 1% of newborn children in the United States. As previously reported, a significant number of CHDs are potentially attributed to altered copy number variants (CNVs). However, as many genomic variants are rare, a large-...

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Bibliografische gegevens
Hoofdauteurs: Yichuan Liu, Xiao Chang, Joseph Glessner, Huiqi Qu, Lifeng Tian, Dong Li, Kenny Nguyen, Patrick M. A. Sleiman, Hakon Hakonarson
Formaat: Artikel
Taal:English
Gepubliceerd in: Frontiers Media S.A. 2019-09-01
Reeks:Frontiers in Genetics
Onderwerpen:
copy number variants
next-generation sequencing
congenital heart defects
large trios study
genomics
Online toegang:https://www.frontiersin.org/article/10.3389/fgene.2019.00819/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00819/full

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