The genetic etiology of body fluids on chronic obstructive airways disease
Abstract Background Numerous studies have documented significant alterations in the bodily fluids of Chronic Obstructive Pulmonary Disease (COPD) patients. However, existing literature lacks causal inference due to residual confounding and reverse causality. Methods Summary-level data for COPD were...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Respiratory Research |
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| Online Access: | https://doi.org/10.1186/s12931-023-02661-6 |
| _version_ | 1827377213724426240 |
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| author | Zhangkai J. Cheng Haojie Wu Zhenglin Chang Jiahao Cheng Suilin Wang Changlian Liu Yanxi Zhang Shiliang Xu Qiongqiong Wan JinWen Ron Kemin Liu Baoqing Sun |
| author_facet | Zhangkai J. Cheng Haojie Wu Zhenglin Chang Jiahao Cheng Suilin Wang Changlian Liu Yanxi Zhang Shiliang Xu Qiongqiong Wan JinWen Ron Kemin Liu Baoqing Sun |
| author_sort | Zhangkai J. Cheng |
| collection | DOAJ |
| description | Abstract Background Numerous studies have documented significant alterations in the bodily fluids of Chronic Obstructive Pulmonary Disease (COPD) patients. However, existing literature lacks causal inference due to residual confounding and reverse causality. Methods Summary-level data for COPD were obtained from two national biobanks: the UK Biobank, comprising 1,605 cases and 461,328 controls, and FinnGen, with 6,915 cases and 186,723 controls. We also validated our findings using clinical data from 2,690 COPD patients and 3,357 healthy controls from the First Affiliated Hospital of Guangzhou Medical University. A total of 44 bodily fluid biomarkers were selected as candidate risk factors. Mendelian randomization (MR) and meta-analyses were used to evaluate the causal effects of these bodily fluids on COPD and lung function (FEV1/FVC). Results Mendelian randomization (MR) and meta-analyses, by integrating data from the UK Biobank and FinnGen cohort, found that 3 bodily fluids indicators (HDLC, EOS, and TP) were causally associated with the risk of COPD, two (EOS and TP) of which is consistent with our observational findings. Moreover, we noticed EOS and TP were causally associated with the risk of lung function (FEV1/FVC). Conclusions The MR findings and clinical data highlight the independent and significant roles of EOS and TP in the development of COPD and lung function (FEV1/FVC), which might provide a deeper insight into COPD risk factors and supply potential preventative strategies. |
| first_indexed | 2024-03-08T12:35:47Z |
| format | Article |
| id | doaj.art-c4c89073e3064a47a3da606a8edffdaa |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-03-08T12:35:47Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-c4c89073e3064a47a3da606a8edffdaa2024-01-21T12:31:19ZengBMCRespiratory Research1465-993X2024-01-012511910.1186/s12931-023-02661-6The genetic etiology of body fluids on chronic obstructive airways diseaseZhangkai J. Cheng0Haojie Wu1Zhenglin Chang2Jiahao Cheng3Suilin Wang4Changlian Liu5Yanxi Zhang6Shiliang Xu7Qiongqiong Wan8JinWen Ron9Kemin Liu10Baoqing Sun11Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou University of Chinese MedicineDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical UniversityAbstract Background Numerous studies have documented significant alterations in the bodily fluids of Chronic Obstructive Pulmonary Disease (COPD) patients. However, existing literature lacks causal inference due to residual confounding and reverse causality. Methods Summary-level data for COPD were obtained from two national biobanks: the UK Biobank, comprising 1,605 cases and 461,328 controls, and FinnGen, with 6,915 cases and 186,723 controls. We also validated our findings using clinical data from 2,690 COPD patients and 3,357 healthy controls from the First Affiliated Hospital of Guangzhou Medical University. A total of 44 bodily fluid biomarkers were selected as candidate risk factors. Mendelian randomization (MR) and meta-analyses were used to evaluate the causal effects of these bodily fluids on COPD and lung function (FEV1/FVC). Results Mendelian randomization (MR) and meta-analyses, by integrating data from the UK Biobank and FinnGen cohort, found that 3 bodily fluids indicators (HDLC, EOS, and TP) were causally associated with the risk of COPD, two (EOS and TP) of which is consistent with our observational findings. Moreover, we noticed EOS and TP were causally associated with the risk of lung function (FEV1/FVC). Conclusions The MR findings and clinical data highlight the independent and significant roles of EOS and TP in the development of COPD and lung function (FEV1/FVC), which might provide a deeper insight into COPD risk factors and supply potential preventative strategies.https://doi.org/10.1186/s12931-023-02661-6COPDBodily fluidsMendelian randomizationGenome-wide analysis |
| spellingShingle | Zhangkai J. Cheng Haojie Wu Zhenglin Chang Jiahao Cheng Suilin Wang Changlian Liu Yanxi Zhang Shiliang Xu Qiongqiong Wan JinWen Ron Kemin Liu Baoqing Sun The genetic etiology of body fluids on chronic obstructive airways disease Respiratory Research COPD Bodily fluids Mendelian randomization Genome-wide analysis |
| title | The genetic etiology of body fluids on chronic obstructive airways disease |
| title_full | The genetic etiology of body fluids on chronic obstructive airways disease |
| title_fullStr | The genetic etiology of body fluids on chronic obstructive airways disease |
| title_full_unstemmed | The genetic etiology of body fluids on chronic obstructive airways disease |
| title_short | The genetic etiology of body fluids on chronic obstructive airways disease |
| title_sort | genetic etiology of body fluids on chronic obstructive airways disease |
| topic | COPD Bodily fluids Mendelian randomization Genome-wide analysis |
| url | https://doi.org/10.1186/s12931-023-02661-6 |
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