Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity
The maintenance of T resident memory (TRM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary TRM cells within specific locational niches.
Bibliographic Details
| Main Authors: |
Anukul T. Shenoy,
Carolina Lyon De Ana,
Emad I. Arafa,
Isabelle Salwig,
Kimberly A. Barker,
Filiz T. Korkmaz,
Aditya Ramanujan,
Neelou S. Etesami,
Alicia M. Soucy,
Ian M. C. Martin,
Brian R. Tilton,
Anne Hinds,
Wesley N. Goltry,
Hasmeena Kathuria,
Thomas Braun,
Matthew R. Jones,
Lee J. Quinton,
Anna C. Belkina,
Joseph P. Mizgerd |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-26045-w
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