Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity
The maintenance of T resident memory (TRM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary TRM cells within specific locational niches.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26045-w |
| _version_ | 1831834091470716928 |
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| author | Anukul T. Shenoy Carolina Lyon De Ana Emad I. Arafa Isabelle Salwig Kimberly A. Barker Filiz T. Korkmaz Aditya Ramanujan Neelou S. Etesami Alicia M. Soucy Ian M. C. Martin Brian R. Tilton Anne Hinds Wesley N. Goltry Hasmeena Kathuria Thomas Braun Matthew R. Jones Lee J. Quinton Anna C. Belkina Joseph P. Mizgerd |
| author_facet | Anukul T. Shenoy Carolina Lyon De Ana Emad I. Arafa Isabelle Salwig Kimberly A. Barker Filiz T. Korkmaz Aditya Ramanujan Neelou S. Etesami Alicia M. Soucy Ian M. C. Martin Brian R. Tilton Anne Hinds Wesley N. Goltry Hasmeena Kathuria Thomas Braun Matthew R. Jones Lee J. Quinton Anna C. Belkina Joseph P. Mizgerd |
| author_sort | Anukul T. Shenoy |
| collection | DOAJ |
| description | The maintenance of T resident memory (TRM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary TRM cells within specific locational niches. |
| first_indexed | 2024-12-23T04:07:42Z |
| format | Article |
| id | doaj.art-c4c893d49d55411c8e49e957418469ec |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T04:07:42Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c4c893d49d55411c8e49e957418469ec2022-12-21T18:00:36ZengNature PortfolioNature Communications2041-17232021-10-0112111610.1038/s41467-021-26045-wAntigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunityAnukul T. Shenoy0Carolina Lyon De Ana1Emad I. Arafa2Isabelle Salwig3Kimberly A. Barker4Filiz T. Korkmaz5Aditya Ramanujan6Neelou S. Etesami7Alicia M. Soucy8Ian M. C. Martin9Brian R. Tilton10Anne Hinds11Wesley N. Goltry12Hasmeena Kathuria13Thomas Braun14Matthew R. Jones15Lee J. Quinton16Anna C. Belkina17Joseph P. Mizgerd18Pulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicineDepartment of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL)Pulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicineFlow Cytometry Core Facility, Boston University School of MedicinePulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicineDepartment of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL)Pulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicinePulmonary Center, Boston University School of MedicineThe maintenance of T resident memory (TRM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary TRM cells within specific locational niches.https://doi.org/10.1038/s41467-021-26045-w |
| spellingShingle | Anukul T. Shenoy Carolina Lyon De Ana Emad I. Arafa Isabelle Salwig Kimberly A. Barker Filiz T. Korkmaz Aditya Ramanujan Neelou S. Etesami Alicia M. Soucy Ian M. C. Martin Brian R. Tilton Anne Hinds Wesley N. Goltry Hasmeena Kathuria Thomas Braun Matthew R. Jones Lee J. Quinton Anna C. Belkina Joseph P. Mizgerd Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity Nature Communications |
| title | Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity |
| title_full | Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity |
| title_fullStr | Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity |
| title_full_unstemmed | Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity |
| title_short | Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity |
| title_sort | antigen presentation by lung epithelial cells directs cd4 trm cell function and regulates barrier immunity |
| url | https://doi.org/10.1038/s41467-021-26045-w |
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