Reconnoitering the sequence and structural analysis of Staphylococcus aureus “A” protein
Background: The Staphylococcus aureus “A” protein plays an essential role in the pathogenicity and virulence of this bacterial species. To gain deeper insights into the protein's characteristics, we conducted an in-depth analysis of its sequence and structure. Objective: This study aimed to unr...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | Saudi Journal of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319562X23002577 |
| _version_ | 1797660400804691968 |
|---|---|
| author | Parthasarathy Ranganathan Akila Varatharajan Khaloud Mohammed Alarjani Dunia A Farraj Viji Rajendran |
| author_facet | Parthasarathy Ranganathan Akila Varatharajan Khaloud Mohammed Alarjani Dunia A Farraj Viji Rajendran |
| author_sort | Parthasarathy Ranganathan |
| collection | DOAJ |
| description | Background: The Staphylococcus aureus “A” protein plays an essential role in the pathogenicity and virulence of this bacterial species. To gain deeper insights into the protein's characteristics, we conducted an in-depth analysis of its sequence and structure. Objective: This study aimed to unravel the underlying genetic and structural components that contribute to the protein's functional properties. Results: Utilizing various bioinformatics tools and techniques, we first examined the protein's primary sequence, identifying key amino acid residues and potential functional domains. Additionally, we employed computational modeling and simulation approaches to determine the tertiary structure of the “A” protein. Through this comprehensive analysis, we discovered novel features and interactions within the protein's structure, shedding light on its potential mechanisms of action. Furthermore, we investigated the protein's evolutionary conservation and compared it with related proteins from other bacterial species. Conclusions: Overall, our findings provide valuable insights into the sequence and structure of the Staphylococcus aureus “A” protein, which may have implications for understanding its role in pathogenicity and guiding the development of novel therapeutic strategies. |
| first_indexed | 2024-03-11T18:29:15Z |
| format | Article |
| id | doaj.art-c4c8bc98887b4d3ca4dee60d2d9d5fda |
| institution | Directory Open Access Journal |
| issn | 1319-562X |
| language | English |
| last_indexed | 2024-03-11T18:29:15Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Journal of Biological Sciences |
| spelling | doaj.art-c4c8bc98887b4d3ca4dee60d2d9d5fda2023-10-13T13:52:31ZengElsevierSaudi Journal of Biological Sciences1319-562X2023-10-013010103812Reconnoitering the sequence and structural analysis of Staphylococcus aureus “A” proteinParthasarathy Ranganathan0Akila Varatharajan1Khaloud Mohammed Alarjani2Dunia A Farraj3Viji Rajendran4Faculty of Physiotherapy, Meenakshi Academy of Higher Education and Research, West K.K. Nagar, Chennai – 600078, Tamil Nadu, IndiaCentral Research Laboratory, Department of Research, Meenakshi Academy of Higher Education and Research, West K.K. Nagar, Chennai – 600078, Tamil Nadu, India; Corresponding author at: Central Research Laboratory, Department of Research, Meenakshi Academy of Higher Education and Research, West K.K. Nagar, Chennai 600078, Tamil Nadu, India.Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Marine Science and Convergence Technology, Hanyang University ERICA Campus, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan-si, Gyeonggido 426-791, South KoreaBackground: The Staphylococcus aureus “A” protein plays an essential role in the pathogenicity and virulence of this bacterial species. To gain deeper insights into the protein's characteristics, we conducted an in-depth analysis of its sequence and structure. Objective: This study aimed to unravel the underlying genetic and structural components that contribute to the protein's functional properties. Results: Utilizing various bioinformatics tools and techniques, we first examined the protein's primary sequence, identifying key amino acid residues and potential functional domains. Additionally, we employed computational modeling and simulation approaches to determine the tertiary structure of the “A” protein. Through this comprehensive analysis, we discovered novel features and interactions within the protein's structure, shedding light on its potential mechanisms of action. Furthermore, we investigated the protein's evolutionary conservation and compared it with related proteins from other bacterial species. Conclusions: Overall, our findings provide valuable insights into the sequence and structure of the Staphylococcus aureus “A” protein, which may have implications for understanding its role in pathogenicity and guiding the development of novel therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S1319562X23002577Staphylococcus aureus“A” proteinSequence analysisBioinformatics toolsComputational modelingTherapeutic strategies |
| spellingShingle | Parthasarathy Ranganathan Akila Varatharajan Khaloud Mohammed Alarjani Dunia A Farraj Viji Rajendran Reconnoitering the sequence and structural analysis of Staphylococcus aureus “A” protein Saudi Journal of Biological Sciences Staphylococcus aureus “A” protein Sequence analysis Bioinformatics tools Computational modeling Therapeutic strategies |
| title | Reconnoitering the sequence and structural analysis of Staphylococcus aureus “A” protein |
| title_full | Reconnoitering the sequence and structural analysis of Staphylococcus aureus “A” protein |
| title_fullStr | Reconnoitering the sequence and structural analysis of Staphylococcus aureus “A” protein |
| title_full_unstemmed | Reconnoitering the sequence and structural analysis of Staphylococcus aureus “A” protein |
| title_short | Reconnoitering the sequence and structural analysis of Staphylococcus aureus “A” protein |
| title_sort | reconnoitering the sequence and structural analysis of staphylococcus aureus a protein |
| topic | Staphylococcus aureus “A” protein Sequence analysis Bioinformatics tools Computational modeling Therapeutic strategies |
| url | http://www.sciencedirect.com/science/article/pii/S1319562X23002577 |
| work_keys_str_mv | AT parthasarathyranganathan reconnoiteringthesequenceandstructuralanalysisofstaphylococcusaureusaprotein AT akilavaratharajan reconnoiteringthesequenceandstructuralanalysisofstaphylococcusaureusaprotein AT khaloudmohammedalarjani reconnoiteringthesequenceandstructuralanalysisofstaphylococcusaureusaprotein AT duniaafarraj reconnoiteringthesequenceandstructuralanalysisofstaphylococcusaureusaprotein AT vijirajendran reconnoiteringthesequenceandstructuralanalysisofstaphylococcusaureusaprotein |