3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes
The hair follicle undergoes a regular cycle composed of three phases: anagen, catagen, and telogen. The life of follicular melanocytes is totally linked to the hair cycle; and during anagen or the growth phase, the melanocytes are active and produce the melanin responsible of hair shaft pigmentation...
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.00175/full |
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| author | Meriem Bejaoui Myra O. Villareal Myra O. Villareal Myra O. Villareal Hiroko Isoda Hiroko Isoda Hiroko Isoda |
| author_facet | Meriem Bejaoui Myra O. Villareal Myra O. Villareal Myra O. Villareal Hiroko Isoda Hiroko Isoda Hiroko Isoda |
| author_sort | Meriem Bejaoui |
| collection | DOAJ |
| description | The hair follicle undergoes a regular cycle composed of three phases: anagen, catagen, and telogen. The life of follicular melanocytes is totally linked to the hair cycle; and during anagen or the growth phase, the melanocytes are active and produce the melanin responsible of hair shaft pigmentation. Various signaling pathways regulate the hair growth cycle and, therefore, the pigmentation; we distinguish the Wnt/β-catenin signaling pathway as it plays a major role in the development, growth, and proliferation of the melanocytes and the activation of melanogenesis enzymes and the related transcription factor. In this study, 3,4,5-tri-O-caffeoylquinic acid (TCQA), a caffeoylquinic acid derivative, stimulated the pigmentation in C3H mouse hair follicle, in human melanocytes, and B16F10 melanoma cells. An enhancement in pigmentation associated genes was observed upon TCQA treatment in vivo and in vitro. Interestingly, the expression of β-catenin was remarkably upregulated in mouse treated skin and in pigment cell lines. Moreover, TCQA upregulated CTNNB1 expression after inhibition in human melanocytes. Taken together, this study suggests that TCQA triggered β-catenin activation to enhance the pigmentation during the anagen phase of the hair cycle. |
| first_indexed | 2024-12-12T12:22:08Z |
| format | Article |
| id | doaj.art-c4c96960379046f4b42453458cbea2b4 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T12:22:08Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-c4c96960379046f4b42453458cbea2b42022-12-22T00:24:38ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-03-01810.3389/fcell.2020.001755026943,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target GenesMeriem Bejaoui0Myra O. Villareal1Myra O. Villareal2Myra O. Villareal3Hiroko Isoda4Hiroko Isoda5Hiroko Isoda6School of Integrative and Global Majors (SIGMA), University of Tsukuba, Tsukuba, JapanSchool of Integrative and Global Majors (SIGMA), University of Tsukuba, Tsukuba, JapanFaculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, JapanAlliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba, JapanSchool of Integrative and Global Majors (SIGMA), University of Tsukuba, Tsukuba, JapanFaculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, JapanAlliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba, JapanThe hair follicle undergoes a regular cycle composed of three phases: anagen, catagen, and telogen. The life of follicular melanocytes is totally linked to the hair cycle; and during anagen or the growth phase, the melanocytes are active and produce the melanin responsible of hair shaft pigmentation. Various signaling pathways regulate the hair growth cycle and, therefore, the pigmentation; we distinguish the Wnt/β-catenin signaling pathway as it plays a major role in the development, growth, and proliferation of the melanocytes and the activation of melanogenesis enzymes and the related transcription factor. In this study, 3,4,5-tri-O-caffeoylquinic acid (TCQA), a caffeoylquinic acid derivative, stimulated the pigmentation in C3H mouse hair follicle, in human melanocytes, and B16F10 melanoma cells. An enhancement in pigmentation associated genes was observed upon TCQA treatment in vivo and in vitro. Interestingly, the expression of β-catenin was remarkably upregulated in mouse treated skin and in pigment cell lines. Moreover, TCQA upregulated CTNNB1 expression after inhibition in human melanocytes. Taken together, this study suggests that TCQA triggered β-catenin activation to enhance the pigmentation during the anagen phase of the hair cycle.https://www.frontiersin.org/article/10.3389/fcell.2020.00175/full345-tri-O-caffeoylquinic acidβ-cateninmelanocytesanagen |
| spellingShingle | Meriem Bejaoui Myra O. Villareal Myra O. Villareal Myra O. Villareal Hiroko Isoda Hiroko Isoda Hiroko Isoda 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes Frontiers in Cell and Developmental Biology 3 4 5-tri-O-caffeoylquinic acid β-catenin melanocytes anagen |
| title | 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes |
| title_full | 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes |
| title_fullStr | 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes |
| title_full_unstemmed | 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes |
| title_short | 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes |
| title_sort | 3 4 5 tri o caffeoylquinic acid promoted hair pigmentation through β catenin and its target genes |
| topic | 3 4 5-tri-O-caffeoylquinic acid β-catenin melanocytes anagen |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.00175/full |
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