Improved Binding Affinity of Omicron’s Spike Protein for the Human Angiotensin-Converting Enzyme 2 Receptor Is the Key behind Its Increased Virulence

Improved Binding Affinity of Omicron’s Spike Protein for the Human Angiotensin-Converting Enzyme 2 Receptor Is the Key behind Its Increased Virulence

The new variant of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), Omicron, has been quickly spreading in many countries worldwide. Compared to the original virus, Omicron is characterized by several mutations in its genomic region, including the spike protein’s receptor-binding d...

Full description

Bibliographic Details
Main Authors: Rajender Kumar, Natarajan Arul Murugan, Vaibhav Srivastava
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)
Omicron
human angiotensin-converting enzyme 2 (hACE2)
molecular dynamics simulation
receptor-binding domain (RBD)
receptor-binding motif (RBM)
Online Access:https://www.mdpi.com/1422-0067/23/6/3409

Similar Items

Similar Items