When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives
For decades, numerous seminal studies have built our understanding of the <i>locus coeruleus</i> (LC), the vertebrate brain’s principal noradrenergic system. Containing a numerically small but broadly efferent cell population, the LC provides brain-wide noradrenergic modulation that opti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/5028 |
| _version_ | 1797504443727478784 |
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| author | Alejandro Osorio-Forero Najma Cherrad Lila Banterle Laura M. J. Fernandez Anita Lüthi |
| author_facet | Alejandro Osorio-Forero Najma Cherrad Lila Banterle Laura M. J. Fernandez Anita Lüthi |
| author_sort | Alejandro Osorio-Forero |
| collection | DOAJ |
| description | For decades, numerous seminal studies have built our understanding of the <i>locus coeruleus</i> (LC), the vertebrate brain’s principal noradrenergic system. Containing a numerically small but broadly efferent cell population, the LC provides brain-wide noradrenergic modulation that optimizes network function in the context of attentive and flexible interaction with the sensory environment. This review turns attention to the LC’s roles during sleep. We show that these roles go beyond down-scaled versions of the ones in wakefulness. Novel dynamic assessments of noradrenaline signaling and LC activity uncover a rich diversity of activity patterns that establish the LC as an integral portion of sleep regulation and function. The LC could be involved in beneficial functions for the sleeping brain, and even minute alterations in its functionality may prove quintessential in sleep disorders. |
| first_indexed | 2024-03-10T04:04:38Z |
| format | Article |
| id | doaj.art-c4d064c18ae84b399f40ce3bd41e6768 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:04:38Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c4d064c18ae84b399f40ce3bd41e67682023-11-23T08:25:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01239502810.3390/ijms23095028When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging PerspectivesAlejandro Osorio-Forero0Najma Cherrad1Lila Banterle2Laura M. J. Fernandez3Anita Lüthi4Department of Fundamental Neurosciences, University of Lausanne, CH-1005 Lausanne, SwitzerlandDepartment of Fundamental Neurosciences, University of Lausanne, CH-1005 Lausanne, SwitzerlandDepartment of Fundamental Neurosciences, University of Lausanne, CH-1005 Lausanne, SwitzerlandDepartment of Fundamental Neurosciences, University of Lausanne, CH-1005 Lausanne, SwitzerlandDepartment of Fundamental Neurosciences, University of Lausanne, CH-1005 Lausanne, SwitzerlandFor decades, numerous seminal studies have built our understanding of the <i>locus coeruleus</i> (LC), the vertebrate brain’s principal noradrenergic system. Containing a numerically small but broadly efferent cell population, the LC provides brain-wide noradrenergic modulation that optimizes network function in the context of attentive and flexible interaction with the sensory environment. This review turns attention to the LC’s roles during sleep. We show that these roles go beyond down-scaled versions of the ones in wakefulness. Novel dynamic assessments of noradrenaline signaling and LC activity uncover a rich diversity of activity patterns that establish the LC as an integral portion of sleep regulation and function. The LC could be involved in beneficial functions for the sleeping brain, and even minute alterations in its functionality may prove quintessential in sleep disorders.https://www.mdpi.com/1422-0067/23/9/5028NREM sleepREM sleepmonoaminenoradrenalinearousabilitysleep architecture |
| spellingShingle | Alejandro Osorio-Forero Najma Cherrad Lila Banterle Laura M. J. Fernandez Anita Lüthi When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives International Journal of Molecular Sciences NREM sleep REM sleep monoamine noradrenaline arousability sleep architecture |
| title | When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives |
| title_full | When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives |
| title_fullStr | When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives |
| title_full_unstemmed | When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives |
| title_short | When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives |
| title_sort | when the locus coeruleus speaks up in sleep recent insights emerging perspectives |
| topic | NREM sleep REM sleep monoamine noradrenaline arousability sleep architecture |
| url | https://www.mdpi.com/1422-0067/23/9/5028 |
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