Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising Hydroxyapatite
The natural healing process of bone is impaired in the presence of tumors, trauma, or inflammation, necessitating external assistance for bone regeneration. The limitations of autologous/allogeneic bone grafting are still being discovered as research progresses. Bone tissue engineering (BTE) is now...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/15/12492 |
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| author | Yifan Niu Lei Chen Tianfu Wu |
| author_facet | Yifan Niu Lei Chen Tianfu Wu |
| author_sort | Yifan Niu |
| collection | DOAJ |
| description | The natural healing process of bone is impaired in the presence of tumors, trauma, or inflammation, necessitating external assistance for bone regeneration. The limitations of autologous/allogeneic bone grafting are still being discovered as research progresses. Bone tissue engineering (BTE) is now a crucial component of treating bone injuries and actively works to promote vascularization, a crucial stage in bone repair. A biomaterial with hydroxyapatite (HA), which resembles the mineral makeup of invertebrate bones and teeth, has demonstrated high osteoconductivity, bioactivity, and biocompatibility. However, due to its brittleness and porosity, which restrict its application, scientists have been prompted to explore ways to improve its properties by mixing it with other materials, modifying its structural composition, improving fabrication techniques and growth factor loading, and co-cultivating bone regrowth cells to stimulate vascularization. This review scrutinizes the latest five-year research on HA composite studies aimed at amplifying vascularization in bone regeneration. |
| first_indexed | 2024-03-11T00:24:45Z |
| format | Article |
| id | doaj.art-c4d1db2f967d4040a4887e585b5cf2c8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:24:45Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c4d1db2f967d4040a4887e585b5cf2c82023-11-18T23:05:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124151249210.3390/ijms241512492Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising HydroxyapatiteYifan Niu0Lei Chen1Tianfu Wu2State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaThe natural healing process of bone is impaired in the presence of tumors, trauma, or inflammation, necessitating external assistance for bone regeneration. The limitations of autologous/allogeneic bone grafting are still being discovered as research progresses. Bone tissue engineering (BTE) is now a crucial component of treating bone injuries and actively works to promote vascularization, a crucial stage in bone repair. A biomaterial with hydroxyapatite (HA), which resembles the mineral makeup of invertebrate bones and teeth, has demonstrated high osteoconductivity, bioactivity, and biocompatibility. However, due to its brittleness and porosity, which restrict its application, scientists have been prompted to explore ways to improve its properties by mixing it with other materials, modifying its structural composition, improving fabrication techniques and growth factor loading, and co-cultivating bone regrowth cells to stimulate vascularization. This review scrutinizes the latest five-year research on HA composite studies aimed at amplifying vascularization in bone regeneration.https://www.mdpi.com/1422-0067/24/15/12492hydroxyapatitevascularizationbiomaterialsstructural characterizationcells and growth factor |
| spellingShingle | Yifan Niu Lei Chen Tianfu Wu Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising Hydroxyapatite International Journal of Molecular Sciences hydroxyapatite vascularization biomaterials structural characterization cells and growth factor |
| title | Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising Hydroxyapatite |
| title_full | Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising Hydroxyapatite |
| title_fullStr | Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising Hydroxyapatite |
| title_full_unstemmed | Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising Hydroxyapatite |
| title_short | Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising Hydroxyapatite |
| title_sort | recent advances in bioengineering bone revascularization based on composite materials comprising hydroxyapatite |
| topic | hydroxyapatite vascularization biomaterials structural characterization cells and growth factor |
| url | https://www.mdpi.com/1422-0067/24/15/12492 |
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