GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation.

GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation.

Urogenital tract abnormalities are among the most common congenital defects in humans. Male urogenital development requires Hedgehog-GLI signaling and testicular hormones, but how these pathways interact is unclear. We found that Gli3XtJ mutant mice exhibit cryptorchidism and hypospadias due to loca...

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Bibliographic Details
Main Authors: Anbarasi Kothandapani, Samantha R Lewis, Jessica L Noel, Abbey Zacharski, Kyle Krellwitz, Anna Baines, Stephanie Winske, Chad M Vezina, Elena M Kaftanovskaya, Alexander I Agoulnik, Emily M Merton, Martin J Cohn, Joan S Jorgensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008810

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