CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge

CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge

Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells has resulted in unprecedented rates of long-lasting complete responses in patients with leukemia and lymphoma. However, despite the impressive results in patients with hematologic malignancies, CAR-T cells have showed limited effe...

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Bibliographic Details
Main Authors: Sonia Guedan, Ramon Alemany
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptors (CAR)
oncolytic viruses
solid tumors
immunotherapy
immunosuppressive tumor microenvironment
adoptive cell transfer (ACT)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02460/full

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