Serum Caspase-1 levels in women with polycystic ovary syndrome
Objective: Caspase-1 is implicated in several important inflammatory diseases and controls adipocyte differentiation and insulin sensitivity. Interleukin-10 (IL-10) is an anti-inflammatory cytokine and plays an important role in chronic inflammatory conditions. This study was planned to determine if...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455920300073 |
| _version_ | 1819012902744489984 |
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| author | Umit Cabus Cihan Kabukcu Semin Fenkci Vildan Caner Ozer Oztekin Veysel Fenkci Yasar Enli |
| author_facet | Umit Cabus Cihan Kabukcu Semin Fenkci Vildan Caner Ozer Oztekin Veysel Fenkci Yasar Enli |
| author_sort | Umit Cabus |
| collection | DOAJ |
| description | Objective: Caspase-1 is implicated in several important inflammatory diseases and controls adipocyte differentiation and insulin sensitivity. Interleukin-10 (IL-10) is an anti-inflammatory cytokine and plays an important role in chronic inflammatory conditions. This study was planned to determine if there is any relationship between Caspase-1 and IL-10 levels in women with PCOS. Materials and methods: Forty-two women with PCOS and thirty-seven healthy controls were evaluated in this controlled clinical study. Caspase-1 and IL-10 levels, serum lipid sub-fractions, fasting glucose, fasting insulin and other hormones (gonadotropins, androgens), malondialdehyde (MDA) and glutathione (GSH) levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. Results: Free androgen index (FAI), HOMA-IR, MDA and Caspase-1 levels were significantly higher in subjects with PCOS. However, the women with PCOS had considerably lower GSH concentration levels than healthy subjects. Serum IL-10 levels were higher in study subjects than in controls, though it was statistically insignificant. Caspase-1 was positively associated with IL-10. Conclusion: These outcomes propose that Caspase-1 may have a role in triggering the processes leading to chronic low-grade inflammation in women with PCOS, independent of insulin resistance, androgen excess and oxidative stress. Nevertheless, the precise role of Caspase-1 in the pathogenesis of the disease remains to be elucidated. Keywords: Caspase-1, IL-10, PCOS, Insulin resistance, Oxidative stress |
| first_indexed | 2024-12-21T01:51:26Z |
| format | Article |
| id | doaj.art-c4d62471914a4a0d8f52c3b0f266ad43 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-21T01:51:26Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-c4d62471914a4a0d8f52c3b0f266ad432022-12-21T19:19:53ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592020-03-01592207210Serum Caspase-1 levels in women with polycystic ovary syndromeUmit Cabus0Cihan Kabukcu1Semin Fenkci2Vildan Caner3Ozer Oztekin4Veysel Fenkci5Yasar Enli6Departments of Obstetrics and Gynecology, Pamukkale University, School of Medicine, Denizli, TurkeyDepartments of Obstetrics and Gynecology, Pamukkale University, School of Medicine, Denizli, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Pamukkale University, School of Medicine, Denizli, TurkeyDepartment of Medical Genetics, Pamukkale University, School of Medicine, Denizli, TurkeyDepartments of Obstetrics and Gynecology, Pamukkale University, School of Medicine, Denizli, Turkey; Corresponding author. Yenisehir mah, 41/2 sok Altinportakal Konutlari No:4E, 20125, Denizli, Turkey.Departments of Obstetrics and Gynecology, Pamukkale University, School of Medicine, Denizli, TurkeyDepartment of Biochemistry, Pamukkale University, School of Medicine, Denizli, TurkeyObjective: Caspase-1 is implicated in several important inflammatory diseases and controls adipocyte differentiation and insulin sensitivity. Interleukin-10 (IL-10) is an anti-inflammatory cytokine and plays an important role in chronic inflammatory conditions. This study was planned to determine if there is any relationship between Caspase-1 and IL-10 levels in women with PCOS. Materials and methods: Forty-two women with PCOS and thirty-seven healthy controls were evaluated in this controlled clinical study. Caspase-1 and IL-10 levels, serum lipid sub-fractions, fasting glucose, fasting insulin and other hormones (gonadotropins, androgens), malondialdehyde (MDA) and glutathione (GSH) levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. Results: Free androgen index (FAI), HOMA-IR, MDA and Caspase-1 levels were significantly higher in subjects with PCOS. However, the women with PCOS had considerably lower GSH concentration levels than healthy subjects. Serum IL-10 levels were higher in study subjects than in controls, though it was statistically insignificant. Caspase-1 was positively associated with IL-10. Conclusion: These outcomes propose that Caspase-1 may have a role in triggering the processes leading to chronic low-grade inflammation in women with PCOS, independent of insulin resistance, androgen excess and oxidative stress. Nevertheless, the precise role of Caspase-1 in the pathogenesis of the disease remains to be elucidated. Keywords: Caspase-1, IL-10, PCOS, Insulin resistance, Oxidative stresshttp://www.sciencedirect.com/science/article/pii/S1028455920300073 |
| spellingShingle | Umit Cabus Cihan Kabukcu Semin Fenkci Vildan Caner Ozer Oztekin Veysel Fenkci Yasar Enli Serum Caspase-1 levels in women with polycystic ovary syndrome Taiwanese Journal of Obstetrics & Gynecology |
| title | Serum Caspase-1 levels in women with polycystic ovary syndrome |
| title_full | Serum Caspase-1 levels in women with polycystic ovary syndrome |
| title_fullStr | Serum Caspase-1 levels in women with polycystic ovary syndrome |
| title_full_unstemmed | Serum Caspase-1 levels in women with polycystic ovary syndrome |
| title_short | Serum Caspase-1 levels in women with polycystic ovary syndrome |
| title_sort | serum caspase 1 levels in women with polycystic ovary syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S1028455920300073 |
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